# AutoPaint: A Self-Inpainting Method for Unsupervised Anomaly Detection

arXiv: https://arxiv.org/abs/2305.12358 · HTML: https://mlsanity.com/paper/2305.12358/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 26 of its 56 references that are in the map.
- First posted on arXiv 21 May 2023.

## Builds on (most cited first, 26 of 26)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Free-Form Image Inpainting with Gated Convolution](https://mlsanity.com/paper/1806.03589/) (2018)
- [Image Inpainting for Irregular Holes Using Partial Convolutions](https://mlsanity.com/paper/1804.07723/) (2018)
- [Attention Gated Networks: Learning to Leverage Salient Regions in Medical Images](https://mlsanity.com/paper/1808.08114/) (2018)
- [Autoencoders for Unsupervised Anomaly Segmentation in Brain MR Images: A Comparative Study](https://mlsanity.com/paper/2004.03271/) (2020)
- [Deep Autoencoding Models for Unsupervised Anomaly Segmentation in Brain MR Images](https://mlsanity.com/paper/1804.04488/) (2018)
- [Image inpainting: A review](https://mlsanity.com/paper/1909.06399/) (2019)
- [Bi-Directional ConvLSTM U-Net with Densley Connected Convolutions](https://mlsanity.com/paper/1909.00166/) (2019)
- [PD-GAN: Probabilistic Diverse GAN for Image Inpainting](https://mlsanity.com/paper/2105.02201/) (2021)
- [Unsupervised Anomaly Localization using Variational Auto-Encoders](https://mlsanity.com/paper/1907.02796/) (2019)
- [SegAN: Adversarial Network with Multi-scale L1 Loss for Medical Image Segmentation](https://mlsanity.com/paper/1706.01805/) (2017)
- [Constrained Contrastive Distribution Learning for Unsupervised Anomaly Detection and Localisation in Medical Images](https://mlsanity.com/paper/2103.03423/) (2021)
- [Anomaly Detection-Inspired Few-Shot Medical Image Segmentation Through Self-Supervision With Supervoxels](https://mlsanity.com/paper/2203.02048/) (2022)
- [ET-Net: A Generic Edge-aTtention Guidance Network for Medical Image Segmentation](https://mlsanity.com/paper/1907.10936/) (2019)
- [Challenging Current Semi-Supervised Anomaly Segmentation Methods for Brain MRI](https://mlsanity.com/paper/2109.06023/) (2021)
- [Scale-Space Autoencoders for Unsupervised Anomaly Segmentation in Brain MRI](https://mlsanity.com/paper/2006.12852/) (2020)
- [Brain Tumor Segmentation and Survival Prediction using 3D Attention UNet](https://mlsanity.com/paper/2104.00985/) (2021)
- [Implicit field learning for unsupervised anomaly detection in medical images](https://mlsanity.com/paper/2106.05214/) (2021)
- [ASC-Net : Adversarial-based Selective Network for Unsupervised Anomaly Segmentation](https://mlsanity.com/paper/2103.03664/) (2021)
- [Progressive and Multi-Path Holistically Nested Neural Networks for Pathological Lung Segmentation from CT Images](https://mlsanity.com/paper/1706.03702/) (2017)

## Built on by (most cited first, 3 of 3)

- [Latent Drifting in Diffusion Models for Counterfactual Medical Image Synthesis](https://mlsanity.com/paper/2412.20651/) (2024)
- [VISAGE: Video Synthesis using Action Graphs for Surgery](https://mlsanity.com/paper/2410.17751/) (2024)
- [Evaluation of pseudo-healthy image reconstruction for anomaly detection with deep generative models: Application to brain FDG PET](https://mlsanity.com/paper/2401.16363/) (2024)

## Abstract (arXiv)

Robust and accurate detection and segmentation of heterogenous tumors appearing in different anatomical organs with supervised methods require large-scale labeled datasets covering all possible types of diseases. Due to the unavailability of such rich datasets and the high cost of annotations, unsupervised anomaly detection (UAD) methods have been developed aiming to detect the pathologies as deviation from the normality by utilizing the unlabeled healthy image data. However, developed UAD models are often trained with an incomplete distribution of healthy anatomies and have difficulties in preserving anatomical constraints. This work intends to, first, propose a robust inpainting model to learn the details of healthy anatomies and reconstruct high-resolution images by preserving anatomical constraints. Second, we propose an autoinpainting pipeline to automatically detect tumors, replace their appearance with the learned healthy anatomies, and based on that segment the tumoral volumes in a purely unsupervised fashion. Three imaging datasets, including PET, CT, and PET-CT scans of lung tumors and head and neck tumors, are studied as benchmarks for evaluation. Experimental results demonstrate the significant superiority of the proposed method over a wide range of state-of-the-art UAD methods. Moreover, the unsupervised method we propose produces comparable results to a robust supervised segmentation method when applied to multimodal images.