# Altered Topological Properties of Functional Brain Network Associated with Alzheimer's Disease

arXiv: https://arxiv.org/abs/2305.08159 · HTML: https://mlsanity.com/paper/2305.08159/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 0 of its 66 references that are in the map.
- First posted on arXiv 14 May 2023.

## Built on by (most cited first, 1 of 1)

- [Abnormal Functional Brain Network Connectivity Associated with Alzheimer's Disease](https://mlsanity.com/paper/2305.09186/) (2023)

## Abstract (arXiv)

Functional Magnetic Resonance Imaging (fMRI) is commonly utilized to study human brain activity, including abnormal functional properties related to neurodegenerative diseases. This study aims to investigate the differences in the topological properties of functional brain networks between individuals with Alzheimer's Disease (AD) and normal controls. A total of 590 subjects, consisting of 175 with AD dementia and 415 age-, gender-, and handedness-matched controls, were included. The topological properties of the brain network were quantified using graph-theory-based analyses. The results indicate abnormal network integration and segregation in the AD group. These findings enhance our understanding of AD pathophysiology from a functional brain network structure perspective and may aid in identifying AD biomarkers. Supplementary data to aid in the validation of this research are available at https://github.com/YongchengYAO/AD-FunctionalBrainNetwork.