# Unsupervised Domain Adaptation for Medical Image Segmentation via Feature-space Density Matching

arXiv: https://arxiv.org/abs/2305.05789 · HTML: https://mlsanity.com/paper/2305.05789/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 27 references that are in the map.
- First posted on arXiv 9 May 2023.

## Builds on (most cited first, 17 of 17)

- [Learning Transferable Features with Deep Adaptation Networks](https://mlsanity.com/paper/1502.02791/) (2015)
- [Adversarial Discriminative Domain Adaptation](https://mlsanity.com/paper/1702.05464/) (2017)
- [Learning Robust Global Representations by Penalizing Local Predictive Power](https://mlsanity.com/paper/1905.13549/) (2019)
- [ADVENT: Adversarial Entropy Minimization for Domain Adaptation in Semantic Segmentation](https://mlsanity.com/paper/1811.12833/) (2018)
- [Learning to Adapt Structured Output Space for Semantic Segmentation](https://mlsanity.com/paper/1802.10349/) (2018)
- [FDA: Fourier Domain Adaptation for Semantic Segmentation](https://mlsanity.com/paper/2004.05498/) (2020)
- [Unsupervised Pixel-Level Domain Adaptation with Generative Adversarial Networks](https://mlsanity.com/paper/1612.05424/) (2016)
- [A Fourier-based Framework for Domain Generalization](https://mlsanity.com/paper/2105.11120/) (2021)
- [MMD GAN: Towards Deeper Understanding of Moment Matching Network](https://mlsanity.com/paper/1705.08584/) (2017)
- [Gland Segmentation in Colon Histology Images: The GlaS Challenge Contest](https://mlsanity.com/paper/1603.00275/) (2016)
- [MS-Net: Multi-Site Network for Improving Prostate Segmentation with Heterogeneous MRI Data](https://mlsanity.com/paper/2002.03366/) (2020)
- [Deep Unsupervised Domain Adaptation: A Review of Recent Advances and Perspectives](https://mlsanity.com/paper/2208.07422/) (2022)
- [Unsupervised Domain Adaptation in Semantic Segmentation: a Review](https://mlsanity.com/paper/2005.10876/) (2020)
- [MILD-Net: Minimal Information Loss Dilated Network for Gland Instance Segmentation in Colon Histology Images](https://mlsanity.com/paper/1806.01963/) (2018)
- [Alleviating Semantic-level Shift: A Semi-supervised Domain Adaptation Method for Semantic Segmentation](https://mlsanity.com/paper/2004.00794/) (2020)
- [Deep Learning Based Brain Tumor Segmentation: A Survey](https://mlsanity.com/paper/2007.09479/) (2020)
- [GENs: Generative Encoding Networks](https://mlsanity.com/paper/2010.15283/) (2020)

## Abstract (arXiv)

Semantic segmentation is a critical step in automated image interpretation and analysis where pixels are classified into one or more predefined semantically meaningful classes. Deep learning approaches for semantic segmentation rely on harnessing the power of annotated images to learn features indicative of these semantic classes. Nonetheless, they often fail to generalize when there is a significant domain (i.e., distributional) shift between the training (i.e., source) data and the dataset(s) encountered when deployed (i.e., target), necessitating manual annotations for the target data to achieve acceptable performance. This is especially important in medical imaging because different image modalities have significant intra- and inter-site variations due to protocol and vendor variability. Current techniques are sensitive to hyperparameter tuning and target dataset size. This paper presents an unsupervised domain adaptation approach for semantic segmentation that alleviates the need for annotating target data. Using kernel density estimation, we match the target data distribution to the source in the feature space, particularly when the number of target samples is limited (3% of the target dataset size). We demonstrate the efficacy of our proposed approach on 2 datasets, multisite prostate MRI and histopathology images.