# SynthMix: Mixing up Aligned Synthesis for Medical Cross-Modality Domain Adaptation

arXiv: https://arxiv.org/abs/2305.04156 · HTML: https://mlsanity.com/paper/2305.04156/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 18 references that are in the map.
- First posted on arXiv 7 May 2023.

## Builds on (most cited first, 14 of 14)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [Improved Regularization of Convolutional Neural Networks with Cutout](https://mlsanity.com/paper/1708.04552/) (2017)
- [CyCADA: Cycle-Consistent Adversarial Domain Adaptation](https://mlsanity.com/paper/1711.03213/) (2017)
- [Deep Learning for Medical Image Analysis](https://mlsanity.com/paper/1708.08987/) (2017)
- [Domain Adaptation for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2102.09508/) (2021)
- [CHAOS Challenge -- Combined (CT-MR) Healthy Abdominal Organ Segmentation](https://mlsanity.com/paper/2001.06535/) (2020)
- [Unsupervised Bidirectional Cross-Modality Adaptation via Deeply Synergistic Image and Feature Alignment for Medical Image Segmentation](https://mlsanity.com/paper/2002.02255/) (2020)
- [SynSeg-Net: Synthetic Segmentation Without Target Modality Ground Truth](https://mlsanity.com/paper/1810.06498/) (2018)
- [Unsupervised Instance Segmentation in Microscopy Images via Panoptic Domain Adaptation and Task Re-weighting](https://mlsanity.com/paper/2005.02066/) (2020)
- [Decompose to Adapt: Cross-domain Object Detection via Feature Disentanglement](https://mlsanity.com/paper/2201.01929/) (2022)
- [Unsupervised Domain Adaptive Fundus Image Segmentation with Few Labeled Source Data](https://mlsanity.com/paper/2210.04379/) (2022)

## Built on by (most cited first, 1 of 1)

- [Semantic-aware Random Convolution and Source Matching for Domain Generalization in Medical Image Segmentation](https://mlsanity.com/paper/2512.01510/) (2025)

## Abstract (arXiv)

The adversarial methods showed advanced performance by producing synthetic images to mitigate the domain shift, a common problem due to the hardship of acquiring labelled data in medical field. Most existing studies focus on modifying the network architecture, but little has worked on the GAN training strategy. In this work, we propose SynthMix, an add-on module with a natural yet effective training policy that can promote synthetic quality without altering the network architecture. Following the adversarial philosophy of GAN, we designed a mix-up synthesis scheme termed SynthMix. It coherently mixed up aligned images of real and synthetic samples to stimulate the generation of fine-grained features, examined by an associated Inspector for the domain-specific details. We evaluated our method on two segmentation benchmarks among three publicly available datasets, where our method showed a significant performance gain compared with existing state-of-the-art approaches.