# Evaluating Post-hoc Interpretability with Intrinsic Interpretability

arXiv: https://arxiv.org/abs/2305.03002 · HTML: https://mlsanity.com/paper/2305.03002/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 18 of its 28 references that are in the map.
- First posted on arXiv 4 May 2023.

## Builds on (most cited first, 18 of 18)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [SmoothGrad: removing noise by adding noise](https://mlsanity.com/paper/1706.03825/) (2017)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [This Looks Like That: Deep Learning for Interpretable Image Recognition](https://mlsanity.com/paper/1806.10574/) (2018)
- [Captum: A unified and generic model interpretability library for PyTorch](https://mlsanity.com/paper/2009.07896/) (2020)
- [Rotation Equivariant CNNs for Digital Pathology](https://mlsanity.com/paper/1806.03962/) (2018)
- [Evaluating the visualization of what a Deep Neural Network has learned](https://mlsanity.com/paper/1509.06321/) (2015)
- [What do different evaluation metrics tell us about saliency models?](https://mlsanity.com/paper/1604.03605/) (2016)
- [IAIA-BL: A Case-based Interpretable Deep Learning Model for Classification of Mass Lesions in Digital Mammography](https://mlsanity.com/paper/2103.12308/) (2021)
- [A causal framework for explaining the predictions of black-box sequence-to-sequence models](https://mlsanity.com/paper/1707.01943/) (2017)
- [Generation of Multimodal Justification Using Visual Word Constraint Model for Explainable Computer-Aided Diagnosis](https://mlsanity.com/paper/1906.03922/) (2019)
- [Patchnet: Interpretable Neural Networks for Image Classification](https://mlsanity.com/paper/1705.08078/) (2017)

## Abstract (arXiv)

Despite Convolutional Neural Networks having reached human-level performance in some medical tasks, their clinical use has been hindered by their lack of interpretability. Two major interpretability strategies have been proposed to tackle this problem: post-hoc methods and intrinsic methods. Although there are several post-hoc methods to interpret DL models, there is significant variation between the explanations provided by each method, and it a difficult to validate them due to the lack of ground-truth. To address this challenge, we adapted the intrinsical interpretable ProtoPNet for the context of histopathology imaging and compared the attribution maps produced by it and the saliency maps made by post-hoc methods. To evaluate the similarity between saliency map methods and attribution maps we adapted 10 saliency metrics from the saliency model literature, and used the breast cancer metastases detection dataset PatchCamelyon with 327,680 patches of histopathological images of sentinel lymph node sections to validate the proposed approach. Overall, SmoothGrad and Occlusion were found to have a statistically bigger overlap with ProtoPNet while Deconvolution and Lime have been found to have the least.