# A new method using deep learning to predict the response to cardiac resynchronization therapy

arXiv: https://arxiv.org/abs/2305.02475 · HTML: https://mlsanity.com/paper/2305.02475/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 87 references that are in the map.
- First posted on arXiv 4 May 2023.

## Builds on (most cited first, 9 of 9)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Comprehensive Survey on Transfer Learning](https://mlsanity.com/paper/1911.02685/) (2019)
- [A Survey on Visual Transformer](https://mlsanity.com/paper/2012.12556/) (2020)
- [Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning](https://mlsanity.com/paper/1602.03409/) (2016)
- [Large Scale Fine-Grained Categorization and Domain-Specific Transfer Learning](https://mlsanity.com/paper/1806.06193/) (2018)
- [A method using deep learning to discover new predictors of CRT response from mechanical dyssynchrony on gated SPECT MPI](https://mlsanity.com/paper/2106.01355/) (2021)

## Abstract (arXiv)

Background. Clinical parameters measured from gated single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) have value in predicting cardiac resynchronization therapy (CRT) patient outcomes, but still show limitations. The purpose of this study is to combine clinical variables, features from electrocardiogram (ECG), and parameters from assessment of cardiac function with polarmaps from gated SPECT MPI through deep learning (DL) to predict CRT response. Methods. 218 patients who underwent rest gated SPECT MPI were enrolled in this study. CRT response was defined as an increase in left ventricular ejection fraction (LVEF) > 5% at a 6-month follow up. A DL model was constructed by combining a pre-trained VGG16 module and a multilayer perceptron. Two modalities of data were input to the model: polarmap images from SPECT MPI and tabular data from clinical features and ECG parameters. Gradient-weighted Class Activation Mapping (Grad-CAM) was applied to the VGG16 module to provide explainability for the polarmaps. For comparison, four machine learning (ML) models were trained using only the tabular features. Results. Modeling was performed on 218 patients who underwent CRT implantation with a response rate of 55.5% (n = 121). The DL model demonstrated average AUC (0.83), accuracy (0.73), sensitivity (0.76), and specificity (0.69) surpassing the ML models and guideline criteria. Guideline recommendations presented accuracy (0.53), sensitivity (0.75), and specificity (0.26). Conclusions. The DL model outperformed the ML models, showcasing the additional predictive benefit of utilizing SPECT MPI polarmaps. Incorporating additional patient data directly in the form of medical imagery can improve CRT response prediction.