# SCOPE: Structural Continuity Preservation for Medical Image Segmentation

arXiv: https://arxiv.org/abs/2304.14572 · HTML: https://mlsanity.com/paper/2304.14572/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 17 of its 27 references that are in the map.
- First posted on arXiv 28 Apr 2023.

## Builds on (most cited first, 17 of 17)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [Road Extraction by Deep Residual U-Net](https://mlsanity.com/paper/1711.10684/) (2017)
- [clDice -- A Novel Topology-Preserving Loss Function for Tubular Structure Segmentation](https://mlsanity.com/paper/2003.07311/) (2020)
- [A Topological Loss Function for Deep-Learning based Image Segmentation using Persistent Homology](https://mlsanity.com/paper/1910.01877/) (2019)
- [SA-UNet: Spatial Attention U-Net for Retinal Vessel Segmentation](https://mlsanity.com/paper/2004.03696/) (2020)
- [IterNet: Retinal Image Segmentation Utilizing Structural Redundancy in Vessel Networks](https://mlsanity.com/paper/1912.05763/) (2019)
- [Deep Vessel Segmentation By Learning Graphical Connectivity](https://mlsanity.com/paper/1806.02279/) (2018)
- [Deep Retinal Image Understanding](https://mlsanity.com/paper/1609.01103/) (2016)
- [LadderNet: Multi-path networks based on U-Net for medical image segmentation](https://mlsanity.com/paper/1810.07810/) (2018)
- [RV-GAN: Segmenting Retinal Vascular Structure in Fundus Photographs using a Novel Multi-scale Generative Adversarial Network](https://mlsanity.com/paper/2101.00535/) (2021)
- [Study Group Learning: Improving Retinal Vessel Segmentation Trained with Noisy Labels](https://mlsanity.com/paper/2103.03451/) (2021)
- [A Learning-based Framework for Topology-Preserving Segmentation using Quasiconformal Mappings](https://mlsanity.com/paper/2210.03299/) (2022)
- [Euler Characteristic Surfaces](https://mlsanity.com/paper/2102.08260/) (2021)
- [TEDS-Net: Enforcing Diffeomorphisms in Spatial Transformers to Guarantee Topology Preservation in Segmentations](https://mlsanity.com/paper/2107.13542/) (2021)

## Built on by (most cited first, 2 of 2)

- [Enhancing the automatic segmentation and analysis of 3D liver vasculature models](https://mlsanity.com/paper/2411.15778/) (2024)
- [Bi-CRCL: Bidirectional Conservative-Radical Complementary Learning with Pre-trained Foundation Models for Class-incremental Medical Image Analysis](https://mlsanity.com/paper/2603.23729/) (2026)

## Abstract (arXiv)

Although the preservation of shape continuity and physiological anatomy is a natural assumption in the segmentation of medical images, it is often neglected by deep learning methods that mostly aim for the statistical modeling of input data as pixels rather than interconnected structures. In biological structures, however, organs are not separate entities; for example, in reality, a severed vessel is an indication of an underlying problem, but traditional segmentation models are not designed to strictly enforce the continuity of anatomy, potentially leading to inaccurate medical diagnoses. To address this issue, we propose a graph-based approach that enforces the continuity and connectivity of anatomical topology in medical images. Our method encodes the continuity of shapes as a graph constraint, ensuring that the network's predictions maintain this continuity. We evaluate our method on two public benchmarks on retinal vessel segmentation, showing significant improvements in connectivity metrics compared to traditional methods while getting better or on-par performance on segmentation metrics.