# PMC-LLaMA: Towards Building Open-source Language Models for Medicine

arXiv: https://arxiv.org/abs/2304.14454 · HTML: https://mlsanity.com/paper/2304.14454/

## Key facts

- Cited by 88 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 29 references that are in the map.
- First posted on arXiv 27 Apr 2023.

## Builds on (most cited first, 15 of 15)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [Scaling Instruction-Finetuned Language Models](https://mlsanity.com/paper/2210.11416/) (2022)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [GLM: General Language Model Pretraining with Autoregressive Blank Infilling](https://mlsanity.com/paper/2103.10360/) (2021)
- [Training Deep Nets with Sublinear Memory Cost](https://mlsanity.com/paper/1604.06174/) (2016)
- [Instruction Tuning with GPT-4](https://mlsanity.com/paper/2304.03277/) (2023)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [OPT-IML: Scaling Language Model Instruction Meta Learning through the Lens of Generalization](https://mlsanity.com/paper/2212.12017/) (2022)

## Built on by (most cited first, 30 of 88)

- [PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answering](https://mlsanity.com/paper/2305.10415/) (2023)
- [A Survey on Knowledge Distillation of Large Language Models](https://mlsanity.com/paper/2402.13116/) (2024)
- [Continual Learning of Large Language Models: A Comprehensive Survey](https://mlsanity.com/paper/2404.16789/) (2024)
- [AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments](https://mlsanity.com/paper/2405.07960/) (2024)
- [MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoning](https://mlsanity.com/paper/2406.00922/) (2024)
- [A Review of Large Language Models and Autonomous Agents in Chemistry](https://mlsanity.com/paper/2407.01603/) (2024)
- [Medical Graph RAG: Towards Safe Medical Large Language Model via Graph Retrieval-Augmented Generation](https://mlsanity.com/paper/2408.04187/) (2024)
- [InstructMol: Multi-Modal Integration for Building a Versatile and Reliable Molecular Assistant in Drug Discovery](https://mlsanity.com/paper/2311.16208/) (2023)
- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [UltraMedical: Building Specialized Generalists in Biomedicine](https://mlsanity.com/paper/2406.03949/) (2024)
- [LMFlow: An Extensible Toolkit for Finetuning and Inference of Large Foundation Models](https://mlsanity.com/paper/2306.12420/) (2023)
- [Survey on Knowledge Distillation for Large Language Models: Methods, Evaluation, and Application](https://mlsanity.com/paper/2407.01885/) (2024)
- [Med42 -- Evaluating Fine-Tuning Strategies for Medical LLMs: Full-Parameter vs. Parameter-Efficient Approaches](https://mlsanity.com/paper/2404.14779/) (2024)
- [MedSafetyBench: Evaluating and Improving the Medical Safety of Large Language Models](https://mlsanity.com/paper/2403.03744/) (2024)
- [MedExpQA: Multilingual Benchmarking of Large Language Models for Medical Question Answering](https://mlsanity.com/paper/2404.05590/) (2024)
- [A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontiers](https://mlsanity.com/paper/2508.21148/) (2025)
- [Taiyi: A Bilingual Fine-Tuned Large Language Model for Diverse Biomedical Tasks](https://mlsanity.com/paper/2311.11608/) (2023)
- [Addressing cognitive bias in medical language models](https://mlsanity.com/paper/2402.08113/) (2024)
- [ChatCAD+: Towards a Universal and Reliable Interactive CAD using LLMs](https://mlsanity.com/paper/2305.15964/) (2023)
- [HealthFC: Verifying Health Claims with Evidence-Based Medical Fact-Checking](https://mlsanity.com/paper/2309.08503/) (2023)
- [OphGLM: Training an Ophthalmology Large Language-and-Vision Assistant based on Instructions and Dialogue](https://mlsanity.com/paper/2306.12174/) (2023)
- [GSCo: Towards Generalizable AI in Medicine via Generalist-Specialist Collaboration](https://mlsanity.com/paper/2404.15127/) (2024)
- [JMLR: Joint Medical LLM and Retrieval Training for Enhancing Reasoning and Professional Question Answering Capability](https://mlsanity.com/paper/2402.17887/) (2024)
- [MedBench: A Large-Scale Chinese Benchmark for Evaluating Medical Large Language Models](https://mlsanity.com/paper/2312.12806/) (2023)
- [A Continued Pretrained LLM Approach for Automatic Medical Note Generation](https://mlsanity.com/paper/2403.09057/) (2024)
- [Small Language Models Learn Enhanced Reasoning Skills from Medical Textbooks](https://mlsanity.com/paper/2404.00376/) (2024)
- [Bias patterns in the application of LLMs for clinical decision support: A comprehensive study](https://mlsanity.com/paper/2404.15149/) (2024)
- [Risks from Language Models for Automated Mental Healthcare: Ethics and Structure for Implementation](https://mlsanity.com/paper/2406.11852/) (2024)
- [Efficient Continual Pre-training by Mitigating the Stability Gap](https://mlsanity.com/paper/2406.14833/) (2024)
- [Exploring the Impact of Table-to-Text Methods on Augmenting LLM-based Question Answering with Domain Hybrid Data](https://mlsanity.com/paper/2402.12869/) (2024)

## Abstract (arXiv)

Recently, Large Language Models (LLMs) have showcased remarkable capabilities in natural language understanding. While demonstrating proficiency in everyday conversations and question-answering situations, these models frequently struggle in domains that require precision, such as medical applications, due to their lack of domain-specific knowledge. In this paper, we describe the procedure for building a powerful, open-source language model specifically designed for medicine applications, termed as PMC-LLaMA. Our contributions are threefold: (i) we systematically investigate the process of adapting a general-purpose foundation language model towards medical domain, this involves data-centric knowledge injection through the integration of 4.8M biomedical academic papers and 30K medical textbooks, as well as comprehensive fine-tuning for alignment with domain-specific instructions; (ii) we contribute a large-scale, comprehensive dataset for instruction tuning. This dataset encompasses medical question-answering (QA), rationale for reasoning, and conversational dialogues, comprising a total of 202M tokens; (iii) we conduct thorough ablation studies to demonstrate the effectiveness of each proposed component. While evaluating on various public medical question-answering benchmarks, our lightweight PMCLLaMA, which consists of only 13 billion parameters, exhibits superior performance, even surpassing ChatGPT. All models, codes, datasets can be found in https://github.com/chaoyi-wu/PMC-LLaMA.