# One-Class SVM on siamese neural network latent space for Unsupervised Anomaly Detection on brain MRI White Matter Hyperintensities

arXiv: https://arxiv.org/abs/2304.08058 · HTML: https://mlsanity.com/paper/2304.08058/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 5 of its 14 references that are in the map.
- First posted on arXiv 17 Apr 2023.

## Builds on (most cited first, 5 of 5)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Rethinking Attention with Performers](https://mlsanity.com/paper/2009.14794/) (2020)
- [Autoencoders for Unsupervised Anomaly Segmentation in Brain MR Images: A Comparative Study](https://mlsanity.com/paper/2004.03271/) (2020)

## Built on by (most cited first, 3 of 3)

- [Evaluation of pseudo-healthy image reconstruction for anomaly detection with deep generative models: Application to brain FDG PET](https://mlsanity.com/paper/2401.16363/) (2024)
- [OCSVM-Guided Representation Learning for Unsupervised Anomaly Detection](https://mlsanity.com/paper/2507.21164/) (2025)
- [Anomaly detection in image or latent space of patch-based auto-encoders for industrial image analysis](https://mlsanity.com/paper/2307.02495/) (2023)

## Abstract (arXiv)

Anomaly detection remains a challenging task in neuroimaging when little to no supervision is available and when lesions can be very small or with subtle contrast. Patch-based representation learning has shown powerful representation capacities when applied to industrial or medical imaging and outlier detection methods have been applied successfully to these images. In this work, we propose an unsupervised anomaly detection (UAD) method based on a latent space constructed by a siamese patch-based auto-encoder and perform the outlier detection with a One-Class SVM training paradigm tailored to the lesion detection task in multi-modality neuroimaging. We evaluate performances of this model on a public database, the White Matter Hyperintensities (WMH) challenge and show in par performance with the two best performing state-of-the-art methods reported so far.