# Domain Adaptive Multiple Instance Learning for Instance-level Prediction of Pathological Images

arXiv: https://arxiv.org/abs/2304.03537 · HTML: https://mlsanity.com/paper/2304.03537/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 20 references that are in the map.
- First posted on arXiv 7 Apr 2023.

## Builds on (most cited first, 15 of 15)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Unsupervised Domain Adaptation by Backpropagation](https://mlsanity.com/paper/1409.7495/) (2014)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Maximum Classifier Discrepancy for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1712.02560/) (2017)
- [VisDA: The Visual Domain Adaptation Challenge](https://mlsanity.com/paper/1710.06924/) (2017)
- [Progressive Feature Alignment for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1811.08585/) (2018)
- [Multiple Instance Learning: A Survey of Problem Characteristics and Applications](https://mlsanity.com/paper/1612.03365/) (2016)
- [Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification](https://mlsanity.com/paper/1504.07947/) (2015)
- [Revisiting Multiple Instance Neural Networks](https://mlsanity.com/paper/1610.02501/) (2016)
- [Multi-scale Domain-adversarial Multiple-instance CNN for Cancer Subtype Classification with Unannotated Histopathological Images](https://mlsanity.com/paper/2001.01599/) (2020)
- [Adversarial Domain Adaptation for Classification of Prostate Histopathology Whole-Slide Images](https://mlsanity.com/paper/1806.01357/) (2018)
- [Multi-Stage Pathological Image Classification using Semantic Segmentation](https://mlsanity.com/paper/1910.04473/) (2019)

## Built on by (most cited first, 1 of 1)

- [Advancing Multiple Instance Learning with Continual Learning for Whole Slide Imaging](https://mlsanity.com/paper/2505.10649/) (2025)

## Abstract (arXiv)

Pathological image analysis is an important process for detecting abnormalities such as cancer from cell images. However, since the image size is generally very large, the cost of providing detailed annotations is high, which makes it difficult to apply machine learning techniques. One way to improve the performance of identifying abnormalities while keeping the annotation cost low is to use only labels for each slide, or to use information from another dataset that has already been labeled. However, such weak supervisory information often does not provide sufficient performance. In this paper, we proposed a new task setting to improve the classification performance of the target dataset without increasing annotation costs. And to solve this problem, we propose a pipeline that uses multiple instance learning (MIL) and domain adaptation (DA) methods. Furthermore, in order to combine the supervisory information of both methods effectively, we propose a method to create pseudo-labels with high confidence. We conducted experiments on the pathological image dataset we created for this study and showed that the proposed method significantly improves the classification performance compared to existing methods.