# Rapid prediction of lab-grown tissue properties using deep learning

arXiv: https://arxiv.org/abs/2303.18017 · HTML: https://mlsanity.com/paper/2303.18017/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 7 of its 51 references that are in the map.
- First posted on arXiv 31 Mar 2023.

## Builds on (most cited first, 7 of 7)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [Deep MR to CT Synthesis using Unpaired Data](https://mlsanity.com/paper/1708.01155/) (2017)
- [Astronomia ex machina: a history, primer, and outlook on neural networks in astronomy](https://mlsanity.com/paper/2211.03796/) (2022)
- [Supernova Light Curves Approximation based on Neural Network Models](https://mlsanity.com/paper/2206.13306/) (2022)

## Abstract (arXiv)

The interactions between cells and the extracellular matrix are vital for the self-organisation of tissues. In this paper we present proof-of-concept to use machine learning tools to predict the role of this mechanobiology in the self-organisation of cell-laden hydrogels grown in tethered moulds. We develop a process for the automated generation of mould designs with and without key symmetries. We create a large training set with N=6500 cases by running detailed biophysical simulations of cell-matrix interactions using the contractile network dipole orientation (CONDOR) model for the self-organisation of cellular hydrogels within these moulds. These are used to train an implementation of the textttpix2pix deep learning model, reserving 740 cases that were unseen in the training of the neural network for training and validation. Comparison between the predictions of the machine learning technique and the reserved predictions from the biophysical algorithm show that the machine learning algorithm makes excellent predictions. The machine learning algorithm is significantly faster than the biophysical method, opening the possibility of very high throughput rational design of moulds for pharmaceutical testing, regenerative medicine and fundamental studies of biology. Future extensions for scaffolds and 3D bioprinting will open additional applications.