# ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge

arXiv: https://arxiv.org/abs/2303.14070 · HTML: https://mlsanity.com/paper/2303.14070/

## Key facts

- Cited by 325 papers in the map (data through 14 Oct 2026).
- Builds on 6 of its 19 references that are in the map.
- First posted on arXiv 24 Mar 2023.

## Builds on (most cited first, 6 of 6)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)
- [A Multitask, Multilingual, Multimodal Evaluation of ChatGPT on Reasoning, Hallucination, and Interactivity](https://mlsanity.com/paper/2302.04023/) (2023)
- [SelfCheckGPT: Zero-Resource Black-Box Hallucination Detection for Generative Large Language Models](https://mlsanity.com/paper/2303.08896/) (2023)
- [Raise a Child in Large Language Model: Towards Effective and Generalizable Fine-tuning](https://mlsanity.com/paper/2109.05687/) (2021)

## Built on by (most cited first, 30 of 325)

- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains](https://mlsanity.com/paper/2402.10373/) (2024)
- [A Survey on Knowledge Distillation of Large Language Models](https://mlsanity.com/paper/2402.13116/) (2024)
- [Continual Learning of Large Language Models: A Comprehensive Survey](https://mlsanity.com/paper/2404.16789/) (2024)
- [Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning](https://mlsanity.com/paper/2506.07044/) (2025)
- [Two Tales of Persona in LLMs: A Survey of Role-Playing and Personalization](https://mlsanity.com/paper/2406.01171/) (2024)
- [Survey on Factuality in Large Language Models: Knowledge, Retrieval and Domain-Specificity](https://mlsanity.com/paper/2310.07521/) (2023)
- [Rainbow Teaming: Open-Ended Generation of Diverse Adversarial Prompts](https://mlsanity.com/paper/2402.16822/) (2024)
- [A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethics](https://mlsanity.com/paper/2310.05694/) (2023)
- [Med-HALT: Medical Domain Hallucination Test for Large Language Models](https://mlsanity.com/paper/2307.15343/) (2023)
- [Language Models with Conformal Factuality Guarantees](https://mlsanity.com/paper/2402.10978/) (2024)
- [OpenFedLLM: Training Large Language Models on Decentralized Private Data via Federated Learning](https://mlsanity.com/paper/2402.06954/) (2024)
- [Vision-Language Models for Medical Report Generation and Visual Question Answering: A Review](https://mlsanity.com/paper/2403.02469/) (2024)
- [A Survey of Large Language Models in Medicine: Progress, Application, and Challenge](https://mlsanity.com/paper/2311.05112/) (2023)
- [ChatEDA: A Large Language Model Powered Autonomous Agent for EDA](https://mlsanity.com/paper/2308.10204/) (2023)
- [Keeping LLMs Aligned After Fine-tuning: The Crucial Role of Prompt Templates](https://mlsanity.com/paper/2402.18540/) (2024)
- [A Comprehensive Survey of Scientific Large Language Models and Their Applications in Scientific Discovery](https://mlsanity.com/paper/2406.10833/) (2024)
- [Conversational Health Agents: A Personalized LLM-Powered Agent Framework](https://mlsanity.com/paper/2310.02374/) (2023)
- [Can Knowledge Graphs Reduce Hallucinations in LLMs? : A Survey](https://mlsanity.com/paper/2311.07914/) (2023)
- [Towards Building Multilingual Language Model for Medicine](https://mlsanity.com/paper/2402.13963/) (2024)
- [DISC-MedLLM: Bridging General Large Language Models and Real-World Medical Consultation](https://mlsanity.com/paper/2308.14346/) (2023)
- [AlpaCare:Instruction-tuned Large Language Models for Medical Application](https://mlsanity.com/paper/2310.14558/) (2023)
- [Harmful Fine-tuning Attacks and Defenses for Large Language Models: A Survey](https://mlsanity.com/paper/2409.18169/) (2024)
- [A Survey of Graph Retrieval-Augmented Generation for Customized Large Language Models](https://mlsanity.com/paper/2501.13958/) (2025)
- [Large Language Model (LLM) for Telecommunications: A Comprehensive Survey on Principles, Key Techniques, and Opportunities](https://mlsanity.com/paper/2405.10825/) (2024)
- [MedRAG: Enhancing Retrieval-augmented Generation with Knowledge Graph-Elicited Reasoning for Healthcare Copilot](https://mlsanity.com/paper/2502.04413/) (2025)
- [EduChat: A Large-Scale Language Model-based Chatbot System for Intelligent Education](https://mlsanity.com/paper/2308.02773/) (2023)
- [Foundation Model for Advancing Healthcare: Challenges, Opportunities, and Future Directions](https://mlsanity.com/paper/2404.03264/) (2024)
- [MindMap: Knowledge Graph Prompting Sparks Graph of Thoughts in Large Language Models](https://mlsanity.com/paper/2308.09729/) (2023)
- [Mental-LLM: Leveraging Large Language Models for Mental Health Prediction via Online Text Data](https://mlsanity.com/paper/2307.14385/) (2023)

## Abstract (arXiv)

The primary aim of this research was to address the limitations observed in the medical knowledge of prevalent large language models (LLMs) such as ChatGPT, by creating a specialized language model with enhanced accuracy in medical advice. We achieved this by adapting and refining the large language model meta-AI (LLaMA) using a large dataset of 100,000 patient-doctor dialogues sourced from a widely used online medical consultation platform. These conversations were cleaned and anonymized to respect privacy concerns. In addition to the model refinement, we incorporated a self-directed information retrieval mechanism, allowing the model to access and utilize real-time information from online sources like Wikipedia and data from curated offline medical databases. The fine-tuning of the model with real-world patient-doctor interactions significantly improved the model's ability to understand patient needs and provide informed advice. By equipping the model with self-directed information retrieval from reliable online and offline sources, we observed substantial improvements in the accuracy of its responses. Our proposed ChatDoctor, represents a significant advancement in medical LLMs, demonstrating a significant improvement in understanding patient inquiries and providing accurate advice. Given the high stakes and low error tolerance in the medical field, such enhancements in providing accurate and reliable information are not only beneficial but essential.