# Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Models

arXiv: https://arxiv.org/abs/2303.05977 · HTML: https://mlsanity.com/paper/2303.05977/

## Key facts

- Cited by 58 papers in the map (data through 14 Oct 2026).
- Builds on 21 of its 35 references that are in the map.
- First posted on arXiv 10 Mar 2023.

## Builds on (most cited first, 21 of 21)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [BERTScore: Evaluating Text Generation with BERT](https://mlsanity.com/paper/1904.09675/) (2019)
- [Model-Agnostic Meta-Learning for Fast Adaptation of Deep Networks](https://mlsanity.com/paper/1703.03400/) (2017)
- [Prefix-Tuning: Optimizing Continuous Prompts for Generation](https://mlsanity.com/paper/2101.00190/) (2021)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)
- [The Pile: An 800GB Dataset of Diverse Text for Language Modeling](https://mlsanity.com/paper/2101.00027/) (2020)
- [Multimodal Few-Shot Learning with Frozen Language Models](https://mlsanity.com/paper/2106.13884/) (2021)
- [ClipCap: CLIP Prefix for Image Captioning](https://mlsanity.com/paper/2111.09734/) (2021)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [Medical Visual Question Answering: A Survey](https://mlsanity.com/paper/2111.10056/) (2021)
- [Does CLIP Benefit Visual Question Answering in the Medical Domain as Much as it Does in the General Domain?](https://mlsanity.com/paper/2112.13906/) (2021)
- [Overcoming Data Limitation in Medical Visual Question Answering](https://mlsanity.com/paper/1909.11867/) (2019)
- [MMBERT: Multimodal BERT Pretraining for Improved Medical VQA](https://mlsanity.com/paper/2104.01394/) (2021)
- [Multiple Meta-model Quantifying for Medical Visual Question Answering](https://mlsanity.com/paper/2105.08913/) (2021)
- [Cross-Modal Self-Attention with Multi-Task Pre-Training for Medical Visual Question Answering](https://mlsanity.com/paper/2105.00136/) (2021)
- [Meta Learning to Bridge Vision and Language Models for Multimodal Few-Shot Learning](https://mlsanity.com/paper/2302.14794/) (2023)
- [Clinical Prompt Learning with Frozen Language Models](https://mlsanity.com/paper/2205.05535/) (2022)

## Built on by (most cited first, 30 of 58)

- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Towards Generalist Biomedical AI](https://mlsanity.com/paper/2307.14334/) (2023)
- [BiomedGPT: A Generalist Vision-Language Foundation Model for Diverse Biomedical Tasks](https://mlsanity.com/paper/2305.17100/) (2023)
- [Towards Generalist Foundation Model for Radiology by Leveraging Web-scale 2D&3D Medical Data](https://mlsanity.com/paper/2308.02463/) (2023)
- [BioMedLM: A 2.7B Parameter Language Model Trained On Biomedical Text](https://mlsanity.com/paper/2403.18421/) (2024)
- [MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicine](https://mlsanity.com/paper/2408.02900/) (2024)
- [PathAsst: A Generative Foundation AI Assistant Towards Artificial General Intelligence of Pathology](https://mlsanity.com/paper/2305.15072/) (2023)
- [Prompt Engineering for Healthcare: Methodologies and Applications](https://mlsanity.com/paper/2304.14670/) (2023)
- [KnowledGPT: Enhancing Large Language Models with Retrieval and Storage Access on Knowledge Bases](https://mlsanity.com/paper/2308.11761/) (2023)
- [MedBLIP: Bootstrapping Language-Image Pre-training from 3D Medical Images and Texts](https://mlsanity.com/paper/2305.10799/) (2023)
- [Med-MoE: Mixture of Domain-Specific Experts for Lightweight Medical Vision-Language Models](https://mlsanity.com/paper/2404.10237/) (2024)
- [A Comprehensive Survey of Large Language Models and Multimodal Large Language Models in Medicine](https://mlsanity.com/paper/2405.08603/) (2024)
- [CLIP in Medical Imaging: A Survey](https://mlsanity.com/paper/2312.07353/) (2023)
- [OphGLM: Training an Ophthalmology Large Language-and-Vision Assistant based on Instructions and Dialogue](https://mlsanity.com/paper/2306.12174/) (2023)
- [3D-RAD: A Comprehensive 3D Radiology Med-VQA Dataset with Multi-Temporal Analysis and Diverse Diagnostic Tasks](https://mlsanity.com/paper/2506.11147/) (2025)
- [PeFoMed: Parameter Efficient Fine-tuning of Multimodal Large Language Models for Medical Imaging](https://mlsanity.com/paper/2401.02797/) (2024)
- [Biomedical Visual Instruction Tuning with Clinician Preference Alignment](https://mlsanity.com/paper/2406.13173/) (2024)
- [MC-CoT: A Modular Collaborative CoT Framework for Zero-shot Medical-VQA with LLM and MLLM Integration](https://mlsanity.com/paper/2410.04521/) (2024)
- [R-LLaVA: Improving Med-VQA Understanding through Visual Region of Interest](https://mlsanity.com/paper/2410.20327/) (2024)
- [ChEX: Interactive Localization and Region Description in Chest X-rays](https://mlsanity.com/paper/2404.15770/) (2024)
- [A Survey on Efficient Vision-Language Models](https://mlsanity.com/paper/2504.09724/) (2025)
- [ProtChatGPT: Towards Understanding Proteins with Large Language Models](https://mlsanity.com/paper/2402.09649/) (2024)
- [A Survey on Trustworthiness in Foundation Models for Medical Image Analysis](https://mlsanity.com/paper/2407.15851/) (2024)
- [OmniV-Med: Scaling Medical Vision-Language Model for Universal Visual Understanding](https://mlsanity.com/paper/2504.14692/) (2025)
- [PA-LLaVA: A Large Language-Vision Assistant for Human Pathology Image Understanding](https://mlsanity.com/paper/2408.09530/) (2024)
- [MedThink: Explaining Medical Visual Question Answering via Multimodal Decision-Making Rationale](https://mlsanity.com/paper/2404.12372/) (2024)
- [LLaDA-MedV: Exploring Large Language Diffusion Models for Biomedical Image Understanding](https://mlsanity.com/paper/2508.01617/) (2025)
- [MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolution](https://mlsanity.com/paper/2604.26283/) (2026)
- [A Survey of Medical Vision-and-Language Applications and Their Techniques](https://mlsanity.com/paper/2411.12195/) (2024)
- [MedSeg-R: Reasoning Segmentation in Medical Images with Multimodal Large Language Models](https://mlsanity.com/paper/2506.10465/) (2025)

## Abstract (arXiv)

Medical Visual Question Answering (VQA) is an important challenge, as it would lead to faster and more accurate diagnoses and treatment decisions. Most existing methods approach it as a multi-class classification problem, which restricts the outcome to a predefined closed-set of curated answers. We focus on open-ended VQA and motivated by the recent advances in language models consider it as a generative task. Leveraging pre-trained language models, we introduce a novel method particularly suited for small, domain-specific, medical datasets. To properly communicate the medical images to the language model, we develop a network that maps the extracted visual features to a set of learnable tokens. Then, alongside the question, these learnable tokens directly prompt the language model. We explore recent parameter-efficient fine-tuning strategies for language models, which allow for resource- and data-efficient fine-tuning. We evaluate our approach on the prime medical VQA benchmarks, namely, Slake, OVQA and PathVQA. The results demonstrate that our approach outperforms existing methods across various training settings while also being computationally efficient.