# Does Synthetic Data Generation of LLMs Help Clinical Text Mining?

arXiv: https://arxiv.org/abs/2303.04360 · HTML: https://mlsanity.com/paper/2303.04360/

## Key facts

- Cited by 154 papers in the map (data through 14 Oct 2026).
- Placed in Medical synthetic data and agents, one of 13 directions in Synthetic data and self-improvement for LLMs.
- Builds on 17 of its 49 references that are in the map.
- First posted on arXiv 8 Mar 2023.

## Placed in

- Synthetic data and self-improvement for LLMs / [Medical synthetic data and agents](https://mlsanity.com/synth/medical-synthetic-data-and-agents/)

## Builds on (most cited first, 17 of 17)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Emergent Abilities of Large Language Models](https://mlsanity.com/paper/2206.07682/) (2022)
- [Pre-train, Prompt, and Predict: A Systematic Survey of Prompting Methods in Natural Language Processing](https://mlsanity.com/paper/2107.13586/) (2021)
- [BLOOM: A 176B-Parameter Open-Access Multilingual Language Model](https://mlsanity.com/paper/2211.05100/) (2022)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Is ChatGPT a General-Purpose Natural Language Processing Task Solver?](https://mlsanity.com/paper/2302.06476/) (2023)
- [How Close is ChatGPT to Human Experts? Comparison Corpus, Evaluation, and Detection](https://mlsanity.com/paper/2301.07597/) (2023)
- [Can ChatGPT Understand Too? A Comparative Study on ChatGPT and Fine-tuned BERT](https://mlsanity.com/paper/2302.10198/) (2023)
- [Exploring Chemical Space using Natural Language Processing Methodologies for Drug Discovery](https://mlsanity.com/paper/2002.06053/) (2020)
- [Med7: a transferable clinical natural language processing model for electronic health records](https://mlsanity.com/paper/2003.01271/) (2020)
- [Understanding Clinical Trial Reports: Extracting Medical Entities and Their Relations](https://mlsanity.com/paper/2010.03550/) (2020)
- [Named Entity Recognition for Electronic Health Records: A Comparison of Rule-based and Machine Learning Approaches](https://mlsanity.com/paper/1903.03985/) (2019)

## Built on by (most cited first, 30 of 154)

- [A Survey of Large Language Models](https://mlsanity.com/paper/2303.18223/) (2023)
- [Harnessing the Power of LLMs in Practice: A Survey on ChatGPT and Beyond](https://mlsanity.com/paper/2304.13712/) (2023)
- [A Survey on Knowledge Distillation of Large Language Models](https://mlsanity.com/paper/2402.13116/) (2024)
- [On LLMs-Driven Synthetic Data Generation, Curation, and Evaluation: A Survey](https://mlsanity.com/paper/2406.15126/) (2024)
- [Leak, Cheat, Repeat: Data Contamination and Evaluation Malpractices in Closed-Source LLMs](https://mlsanity.com/paper/2402.03927/) (2024)
- [Red-Teaming Large Language Models using Chain of Utterances for Safety-Alignment](https://mlsanity.com/paper/2308.09662/) (2023)
- [Large Language Models for Generative Information Extraction: A Survey](https://mlsanity.com/paper/2312.17617/) (2023)
- [Summary of ChatGPT-Related Research and Perspective Towards the Future of Large Language Models](https://mlsanity.com/paper/2304.01852/) (2023)
- [How Can Recommender Systems Benefit from Large Language Models: A Survey](https://mlsanity.com/paper/2306.05817/) (2023)
- [Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey](https://mlsanity.com/paper/2305.18703/) (2023)
- [DeID-GPT: Zero-shot Medical Text De-Identification by GPT-4](https://mlsanity.com/paper/2303.11032/) (2023)
- [Synthetic Data Generation with Large Language Models for Text Classification: Potential and Limitations](https://mlsanity.com/paper/2310.07849/) (2023)
- [A Survey of LLM-based Agents in Medicine: How far are we from Baymax?](https://mlsanity.com/paper/2502.11211/) (2025)
- [Self-Adapting Language Models](https://mlsanity.com/paper/2506.10943/) (2025)
- [Explorer: Scaling Exploration-driven Web Trajectory Synthesis for Multimodal Web Agents](https://mlsanity.com/paper/2502.11357/) (2025)
- [Large Language Models and Knowledge Graphs: Opportunities and Challenges](https://mlsanity.com/paper/2308.06374/) (2023)
- [Let the LLMs Talk: Simulating Human-to-Human Conversational QA via Zero-Shot LLM-to-LLM Interactions](https://mlsanity.com/paper/2312.02913/) (2023)
- [Large Language Models Can be Lazy Learners: Analyze Shortcuts in In-Context Learning](https://mlsanity.com/paper/2305.17256/) (2023)
- [Contrasting Linguistic Patterns in Human and LLM-Generated News Text](https://mlsanity.com/paper/2308.09067/) (2023)
- [Key-Point-Driven Data Synthesis with its Enhancement on Mathematical Reasoning](https://mlsanity.com/paper/2403.02333/) (2024)
- [Is In-Context Learning in Large Language Models Bayesian? A Martingale Perspective](https://mlsanity.com/paper/2406.00793/) (2024)
- [A Comprehensive Survey on Vector Database: Storage and Retrieval Technique, Challenge](https://mlsanity.com/paper/2310.11703/) (2023)
- [Zero-shot Temporal Relation Extraction with ChatGPT](https://mlsanity.com/paper/2304.05454/) (2023)
- [Prompting Multilingual Large Language Models to Generate Code-Mixed Texts: The Case of South East Asian Languages](https://mlsanity.com/paper/2303.13592/) (2023)
- [An Empirical Study on Information Extraction using Large Language Models](https://mlsanity.com/paper/2305.14450/) (2023)
- [Peer Review as A Multi-Turn and Long-Context Dialogue with Role-Based Interactions](https://mlsanity.com/paper/2406.05688/) (2024)
- [A Comprehensive Survey of Large Language Models and Multimodal Large Language Models in Medicine](https://mlsanity.com/paper/2405.08603/) (2024)
- [What is the Role of Small Models in the LLM Era: A Survey](https://mlsanity.com/paper/2409.06857/) (2024)
- [Better Synthetic Data by Retrieving and Transforming Existing Datasets](https://mlsanity.com/paper/2404.14361/) (2024)
- [Generative AI for Synthetic Data Generation: Methods, Challenges and the Future](https://mlsanity.com/paper/2403.04190/) (2024)

## Abstract (arXiv)

Recent advancements in large language models (LLMs) have led to the development of highly potent models like OpenAI's ChatGPT. These models have exhibited exceptional performance in a variety of tasks, such as question answering, essay composition, and code generation. However, their effectiveness in the healthcare sector remains uncertain. In this study, we seek to investigate the potential of ChatGPT to aid in clinical text mining by examining its ability to extract structured information from unstructured healthcare texts, with a focus on biological named entity recognition and relation extraction. However, our preliminary results indicate that employing ChatGPT directly for these tasks resulted in poor performance and raised privacy concerns associated with uploading patients' information to the ChatGPT API. To overcome these limitations, we propose a new training paradigm that involves generating a vast quantity of high-quality synthetic data with labels utilizing ChatGPT and fine-tuning a local model for the downstream task. Our method has resulted in significant improvements in the performance of downstream tasks, improving the F1-score from 23.37% to 63.99% for the named entity recognition task and from 75.86% to 83.59% for the relation extraction task. Furthermore, generating data using ChatGPT can significantly reduce the time and effort required for data collection and labeling, as well as mitigate data privacy concerns. In summary, the proposed framework presents a promising solution to enhance the applicability of LLM models to clinical text mining.