# Artificial Intelligence for Dementia Research Methods Optimization

arXiv: https://arxiv.org/abs/2303.01949 · HTML: https://mlsanity.com/paper/2303.01949/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 188 references that are in the map.
- First posted on arXiv 2 Mar 2023.

## Builds on (most cited first, 8 of 8)

- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Automatic chemical design using a data-driven continuous representation of molecules](https://mlsanity.com/paper/1610.02415/) (2016)
- [Autoencoders for Unsupervised Anomaly Segmentation in Brain MR Images: A Comparative Study](https://mlsanity.com/paper/2004.03271/) (2020)
- [Convolutional Neural Networks for Classification of Alzheimer's Disease: Overview and Reproducible Evaluation](https://mlsanity.com/paper/1904.07773/) (2019)
- [The reliability of a deep learning model in clinical out-of-distribution MRI data: a multicohort study](https://mlsanity.com/paper/1911.00515/) (2019)
- [Early Prediction of Alzheimer's Disease Dementia Based on Baseline Hippocampal MRI and 1-Year Follow-Up Cognitive Measures Using Deep Recurrent Neural Networks](https://mlsanity.com/paper/1901.01451/) (2019)
- [Machine learning for modeling the progression of Alzheimer disease dementia using clinical data: a systematic literature review](https://mlsanity.com/paper/2108.04174/) (2021)
- [Ten years of image analysis and machine learning competitions in dementia](https://mlsanity.com/paper/2112.07922/) (2021)

## Abstract (arXiv)

Introduction: Machine learning (ML) has been extremely successful in identifying key features from high-dimensional datasets and executing complicated tasks with human expert levels of accuracy or greater. Methods: We summarize and critically evaluate current applications of ML in dementia research and highlight directions for future research. Results: We present an overview of ML algorithms most frequently used in dementia research and highlight future opportunities for the use of ML in clinical practice, experimental medicine, and clinical trials. We discuss issues of reproducibility, replicability and interpretability and how these impact the clinical applicability of dementia research. Finally, we give examples of how state-of-the-art methods, such as transfer learning, multi-task learning, and reinforcement learning, may be applied to overcome these issues and aid the translation of research to clinical practice in the future. Discussion: ML-based models hold great promise to advance our understanding of the underlying causes and pathological mechanisms of dementia.