# Dissolving Is Amplifying: Towards Fine-Grained Anomaly Detection

arXiv: https://arxiv.org/abs/2302.14696 · HTML: https://mlsanity.com/paper/2302.14696/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 39 of its 71 references that are in the map.
- First posted on arXiv 28 Feb 2023.

## Builds on (most cited first, 30 of 39)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [Exploring Simple Siamese Representation Learning](https://mlsanity.com/paper/2011.10566/) (2020)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [Large Scale GAN Training for High Fidelity Natural Image Synthesis](https://mlsanity.com/paper/1809.11096/) (2018)
- [Improved Baselines with Momentum Contrastive Learning](https://mlsanity.com/paper/2003.04297/) (2020)
- [Big Self-Supervised Models are Strong Semi-Supervised Learners](https://mlsanity.com/paper/2006.10029/) (2020)
- [Mixed Precision Training](https://mlsanity.com/paper/1710.03740/) (2017)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [Large Batch Training of Convolutional Networks](https://mlsanity.com/paper/1708.03888/) (2017)
- [CSI: Novelty Detection via Contrastive Learning on Distributionally Shifted Instances](https://mlsanity.com/paper/2007.08176/) (2020)
- [Anomaly Detection via Reverse Distillation from One-Class Embedding](https://mlsanity.com/paper/2201.10703/) (2022)
- [GANomaly: Semi-Supervised Anomaly Detection via Adversarial Training](https://mlsanity.com/paper/1805.06725/) (2018)
- [Adversarial Autoencoders](https://mlsanity.com/paper/1511.05644/) (2015)
- [Deep Learning for Anomaly Detection: A Survey](https://mlsanity.com/paper/1901.03407/) (2019)
- [CFLOW-AD: Real-Time Unsupervised Anomaly Detection with Localization via Conditional Normalizing Flows](https://mlsanity.com/paper/2107.12571/) (2021)
- [Discriminative Unsupervised Feature Learning with Exemplar Convolutional Neural Networks](https://mlsanity.com/paper/1406.6909/) (2014)
- [Multiresolution Knowledge Distillation for Anomaly Detection](https://mlsanity.com/paper/2011.11108/) (2020)
- [Deep Anomaly Detection Using Geometric Transformations](https://mlsanity.com/paper/1805.10917/) (2018)
- [A Unified Model for Multi-class Anomaly Detection](https://mlsanity.com/paper/2206.03687/) (2022)
- [DatasetGAN: Efficient Labeled Data Factory with Minimal Human Effort](https://mlsanity.com/paper/2104.06490/) (2021)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [FastFlow: Unsupervised Anomaly Detection and Localization via 2D Normalizing Flows](https://mlsanity.com/paper/2111.07677/) (2021)
- [Adversarially Learned One-Class Classifier for Novelty Detection](https://mlsanity.com/paper/1802.09088/) (2018)
- [Skip-GANomaly: Skip Connected and Adversarially Trained Encoder-Decoder Anomaly Detection](https://mlsanity.com/paper/1901.08954/) (2019)

## Built on by (most cited first, 3 of 3)

- [Diffusion Models for Hyperspectral Image Analysis: A Comprehensive Review](https://mlsanity.com/paper/2505.11158/) (2025)
- [Toward Long-Tailed Online Anomaly Detection through Class-Agnostic Concepts](https://mlsanity.com/paper/2507.16946/) (2025)
- [Learning Non-Linear Invariants for Unsupervised Out-of-Distribution Detection](https://mlsanity.com/paper/2407.04022/) (2024)

## Abstract (arXiv)

Medical imaging often contains critical fine-grained features, such as tumors or hemorrhages, crucial for diagnosis yet potentially too subtle for detection with conventional methods. In this paper, we introduce textitDIA, dissolving is amplifying. DIA is a fine-grained anomaly detection framework for medical images. First, we introduce textitdissolving transformations. We employ diffusion with a generative diffusion model as a dedicated feature-aware denoiser. Applying diffusion to medical images in a certain manner can remove or diminish fine-grained discriminative features. Second, we introduce an textitamplifying framework based on contrastive learning to learn a semantically meaningful representation of medical images in a self-supervised manner, with a focus on fine-grained features. The amplifying framework contrasts additional pairs of images with and without dissolving transformations applied and thereby emphasizes the dissolved fine-grained features. DIA significantly improves the medical anomaly detection performance with around 18.40% AUC boost against the baseline method and achieves an overall SOTA against other benchmark methods. Our code is available at urlhttps://github.com/shijianjian/DIA.git.