# Dermatological Diagnosis Explainability Benchmark for Convolutional Neural Networks

arXiv: https://arxiv.org/abs/2302.12084 · HTML: https://mlsanity.com/paper/2302.12084/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 31 of its 96 references that are in the map.
- First posted on arXiv 23 Feb 2023.

## Builds on (most cited first, 30 of 31)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications](https://mlsanity.com/paper/1704.04861/) (2017)
- [Xception: Deep Learning with Depthwise Separable Convolutions](https://mlsanity.com/paper/1610.02357/) (2016)
- [Searching for MobileNetV3](https://mlsanity.com/paper/1905.02244/) (2019)
- [Identity Mappings in Deep Residual Networks](https://mlsanity.com/paper/1603.05027/) (2016)
- [Inception-v4, Inception-ResNet and the Impact of Residual Connections on Learning](https://mlsanity.com/paper/1602.07261/) (2016)
- [ShuffleNet: An Extremely Efficient Convolutional Neural Network for Mobile Devices](https://mlsanity.com/paper/1707.01083/) (2017)
- [Learning Transferable Architectures for Scalable Image Recognition](https://mlsanity.com/paper/1707.07012/) (2017)
- [Transformers in Vision: A Survey](https://mlsanity.com/paper/2101.01169/) (2021)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [European Union regulations on algorithmic decision-making and a "right to explanation"](https://mlsanity.com/paper/1606.08813/) (2016)
- [Explainable Machine Learning for Scientific Insights and Discoveries](https://mlsanity.com/paper/1905.08883/) (2019)
- [A deep learning system for differential diagnosis of skin diseases](https://mlsanity.com/paper/1909.05382/) (2019)
- [Explainable deep learning models in medical image analysis](https://mlsanity.com/paper/2005.13799/) (2020)
- [Does Your Dermatology Classifier Know What It Doesn't Know? Detecting the Long-Tail of Unseen Conditions](https://mlsanity.com/paper/2104.03829/) (2021)
- [Deep neural network or dermatologist?](https://mlsanity.com/paper/1908.06612/) (2019)
- [DermX: an end-to-end framework for explainable automated dermatological diagnosis](https://mlsanity.com/paper/2202.06956/) (2022)
- [Explainable Image Quality Assessments in Teledermatological Photography](https://mlsanity.com/paper/2209.04699/) (2022)

## Built on by (most cited first, 1 of 1)

- [Onto-Epistemological Analysis of AI Explanations](https://mlsanity.com/paper/2510.02996/) (2025)

## Abstract (arXiv)

In recent years, large strides have been taken in developing machine learning methods for dermatological applications, supported in part by the success of deep learning (DL). To date, diagnosing diseases from images is one of the most explored applications of DL within dermatology. Convolutional neural networks (ConvNets) are the most common (DL) method in medical imaging due to their training efficiency and accuracy, although they are often described as black boxes because of their limited explainability. One popular way to obtain insight into a ConvNet's decision mechanism is gradient class activation maps (Grad-CAM). A quantitative evaluation of the Grad-CAM explainability has been recently made possible by the release of DermXDB, a skin disease diagnosis explainability dataset which enables explainability benchmarking of ConvNet architectures. In this paper, we perform a literature review to identify the most common ConvNet architectures used for this task, and compare their Grad-CAM explanations with the explanation maps provided by DermXDB. We identified 11 architectures: DenseNet121, EfficientNet-B0, InceptionV3, InceptionResNetV2, MobileNet, MobileNetV2, NASNetMobile, ResNet50, ResNet50V2, VGG16, and Xception. We pre-trained all architectures on an clinical skin disease dataset, and fine-tuned them on a DermXDB subset. Validation results on the DermXDB holdout subset show an explainability F1 score of between 0.35-0.46, with Xception displaying the highest explainability performance. NASNetMobile reports the highest characteristic-level explainability sensitivity, despite it's mediocre diagnosis performance. These results highlight the importance of choosing the right architecture for the desired application and target market, underline need for additional explainability datasets, and further confirm the need for explainability benchmarking that relies on quantitative analyses.