# Is Autoencoder Truly Applicable for 3D CT Super-Resolution?

arXiv: https://arxiv.org/abs/2302.10272 · HTML: https://mlsanity.com/paper/2302.10272/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 5 of its 11 references that are in the map.
- First posted on arXiv 23 Jan 2023.

## Builds on (most cited first, 5 of 5)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Enhanced Deep Residual Networks for Single Image Super-Resolution](https://mlsanity.com/paper/1707.02921/) (2017)
- [Multi-Task Attention-Based Semi-Supervised Learning for Medical Image Segmentation](https://mlsanity.com/paper/1907.12303/) (2019)
- [Virtual Thin Slice: 3D Conditional GAN-based Super-resolution for CT Slice Interval](https://mlsanity.com/paper/1908.11506/) (2019)

## Built on by (most cited first, 1 of 1)

- [Enhancing Super-Resolution Networks through Realistic Thick-Slice CT Simulation](https://mlsanity.com/paper/2307.10182/) (2023)

## Abstract (arXiv)

Featured by a bottleneck structure, autoencoder (AE) and its variants have been largely applied in various medical image analysis tasks, such as segmentation, reconstruction and de-noising. Despite of their promising performances in aforementioned tasks, in this paper, we claim that AE models are not applicable to single image super-resolution (SISR) for 3D CT data. Our hypothesis is that the bottleneck architecture that resizes feature maps in AE models degrades the details of input images, thus can sabotage the performance of super-resolution. Although U-Net proposed skip connections that merge information from different levels, we claim that the degrading impact of feature resizing operations could hardly be removed by skip connections. By conducting large-scale ablation experiments and comparing the performance between models with and without the bottleneck design on a public CT lung dataset , we have discovered that AE models, including U-Net, have failed to achieve a compatible SISR result (p<0.05 by Student's t-test) compared to the baseline model. Our work is the first comparative study investigating the suitability of AE architecture for 3D CT SISR tasks and brings a rationale for researchers to re-think the choice of model architectures especially for 3D CT SISR tasks. The full implementation and trained models can be found at: https://github.com/Roldbach/Autoencoder-3D-CT-SISR