# Positive-unlabeled learning for binary and multi-class cell detection in histopathology images with incomplete annotations

arXiv: https://arxiv.org/abs/2302.08050 · HTML: https://mlsanity.com/paper/2302.08050/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 38 references that are in the map.
- First posted on arXiv 16 Feb 2023.

## Builds on (most cited first, 15 of 15)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [Cascade R-CNN: High Quality Object Detection and Instance Segmentation](https://mlsanity.com/paper/1906.09756/) (2019)
- [Positive-Unlabeled Learning with Non-Negative Risk Estimator](https://mlsanity.com/paper/1703.00593/) (2017)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Deep Learning-based Computational Pathology Predicts Origins for Cancers of Unknown Primary](https://mlsanity.com/paper/2006.13932/) (2020)
- [Predicting breast tumor proliferation from whole-slide images: the TUPAC16 challenge](https://mlsanity.com/paper/1807.08284/) (2018)
- [NuCLS: A scalable crowdsourcing, deep learning approach and dataset for nucleus classification, localization and segmentation](https://mlsanity.com/paper/2102.09099/) (2021)
- [Signet Ring Cell Detection With a Semi-supervised Learning Framework](https://mlsanity.com/paper/1907.03954/) (2019)
- [Object Detection as a Positive-Unlabeled Problem](https://mlsanity.com/paper/2002.04672/) (2020)
- [Are pathologist-defined labels reproducible? Comparison of the TUPAC16 mitotic figure dataset with an alternative set of labels](https://mlsanity.com/paper/2007.05351/) (2020)
- [Positive-unlabeled Learning for Cell Detection in Histopathology Images with Incomplete Annotations](https://mlsanity.com/paper/2106.15918/) (2021)

## Built on by (most cited first, 1 of 1)

- [Few Dimensions are Enough: Fine-tuning BERT with Selected Dimensions Revealed Its Redundant Nature](https://mlsanity.com/paper/2504.04966/) (2025)

## Abstract (arXiv)

Cell detection in histopathology images is of great interest to clinical practice and research, and convolutional neural networks (CNNs) have achieved remarkable cell detection results. Typically, to train CNN-based cell detection models, every positive instance in the training images needs to be annotated, and instances that are not labeled as positive are considered negative samples. However, manual cell annotation is complicated due to the large number and diversity of cells, and it can be difficult to ensure the annotation of every positive instance. In many cases, only incomplete annotations are available, where some of the positive instances are annotated and the others are not, and the classification loss term for negative samples in typical network training becomes incorrect. In this work, to address this problem of incomplete annotations, we propose to reformulate the training of the detection network as a positive-unlabeled learning problem. Since the instances in unannotated regions can be either positive or negative, they have unknown labels. Using the samples with unknown labels and the positively labeled samples, we first derive an approximation of the classification loss term corresponding to negative samples for binary cell detection, and based on this approximation we further extend the proposed framework to multi-class cell detection. For evaluation, experiments were performed on four publicly available datasets. The experimental results show that our method improves the performance of cell detection in histopathology images given incomplete annotations for network training.