# Deep Learning Predicts Prevalent and Incident Parkinson's Disease From UK Biobank Fundus Imaging

arXiv: https://arxiv.org/abs/2302.06727 · HTML: https://mlsanity.com/paper/2302.06727/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 8 of its 51 references that are in the map.
- First posted on arXiv 13 Feb 2023.

## Builds on (most cited first, 8 of 8)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [On the (In)fidelity and Sensitivity for Explanations](https://mlsanity.com/paper/1901.09392/) (2019)
- [Evaluation of Retinal Image Quality Assessment Networks in Different Color-spaces](https://mlsanity.com/paper/1907.05345/) (2019)

## Built on by (most cited first, 1 of 1)

- [Adaptive Wavelet Filters as Practical Texture Feature Amplifiers for Parkinson's Disease Screening in OCT](https://mlsanity.com/paper/2503.19292/) (2025)

## Abstract (arXiv)

Parkinson's disease is the world's fastest-growing neurological disorder. Research to elucidate the mechanisms of Parkinson's disease and automate diagnostics would greatly improve the treatment of patients with Parkinson's disease. Current diagnostic methods are expensive and have limited availability. Considering the insidious and preclinical onset and progression of the disease, a desirable screening should be diagnostically accurate even before the onset of symptoms to allow medical interventions. We highlight retinal fundus imaging, often termed a window to the brain, as a diagnostic screening modality for Parkinson's disease. We conducted a systematic evaluation of conventional machine learning and deep learning techniques to classify Parkinson's disease from UK Biobank fundus imaging. Our results show that Parkinson's disease individuals can be differentiated from age and gender-matched healthy subjects with an Area Under the Curve (AUC) of 0.77. This accuracy is maintained when predicting either prevalent or incident Parkinson's disease. Explainability and trustworthiness are enhanced by visual attribution maps of localized biomarkers and quantified metrics of model robustness to data perturbations.