# Impact of PCA-based preprocessing and different CNN structures on deformable registration of sonograms

arXiv: https://arxiv.org/abs/2301.08802 · HTML: https://mlsanity.com/paper/2301.08802/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 16 references that are in the map.
- First posted on arXiv 20 Jan 2023.

## Builds on (most cited first, 10 of 10)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Spatial Transformer Networks](https://mlsanity.com/paper/1506.02025/) (2015)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [Deep Learning in Medical Image Registration: A Review](https://mlsanity.com/paper/1912.12318/) (2019)
- [Weakly-Supervised Convolutional Neural Networks for Multimodal Image Registration](https://mlsanity.com/paper/1807.03361/) (2018)
- [Real-time Deep Pose Estimation with Geodesic Loss for Image-to-Template Rigid Registration](https://mlsanity.com/paper/1803.05982/) (2018)
- [Inverse-Consistent Deep Networks for Unsupervised Deformable Image Registration](https://mlsanity.com/paper/1809.03443/) (2018)
- [An Artificial Agent for Robust Image Registration](https://mlsanity.com/paper/1611.10336/) (2016)
- [Medical Image Registration Using Deep Neural Networks: A Comprehensive Review](https://mlsanity.com/paper/2002.03401/) (2020)
- [Adversarial Image Registration with Application for MR and TRUS Image Fusion](https://mlsanity.com/paper/1804.11024/) (2018)

## Built on by (most cited first, 1 of 1)

- [Deep learning in medical image registration: introduction and survey](https://mlsanity.com/paper/2309.00727/) (2023)

## Abstract (arXiv)

Central venous catheters (CVC) are commonly inserted into the large veins of the neck, e.g. the internal jugular vein (IJV). CVC insertion may cause serious complications like misplacement into an artery or perforation of cervical vessels. Placing a CVC under sonographic guidance is an appropriate method to reduce such adverse events, if anatomical landmarks like venous and arterial vessels can be detected reliably. This task shall be solved by registration of patient individual images vs. an anatomically labelled reference image. In this work, a linear, affine transformation is performed on cervical sonograms, followed by a non-linear transformation to achieve a more precise registration. Voxelmorph (VM), a learning-based library for deformable image registration using a convolutional neural network (CNN) with U-Net structure was used for non-linear transformation. The impact of principal component analysis (PCA)-based pre-denoising of patient individual images, as well as the impact of modified net structures with differing complexities on registration results were examined visually and quantitatively, the latter using metrics for deformation and image similarity. Using the PCA-approximated cervical sonograms resulted in decreased mean deformation lengths between 18% and 66% compared to their original image counterparts, depending on net structure. In addition, reducing the number of convolutional layers led to improved image similarity with PCA images, while worsening in original images. Despite a large reduction of network parameters, no overall decrease in registration quality was observed, leading to the conclusion that the original net structure is oversized for the task at hand.