# A Multi-Scale Framework for Out-of-Distribution Detection in Dermoscopic Images

arXiv: https://arxiv.org/abs/2301.07533 · HTML: https://mlsanity.com/paper/2301.07533/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 23 of its 37 references that are in the map.
- First posted on arXiv 18 Jan 2023.

## Builds on (most cited first, 23 of 23)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [A Baseline for Detecting Misclassified and Out-of-Distribution Examples in Neural Networks](https://mlsanity.com/paper/1610.02136/) (2016)
- [A Simple Unified Framework for Detecting Out-of-Distribution Samples and Adversarial Attacks](https://mlsanity.com/paper/1807.03888/) (2018)
- [Enhancing The Reliability of Out-of-distribution Image Detection in Neural Networks](https://mlsanity.com/paper/1706.02690/) (2017)
- [Energy-based Out-of-distribution Detection](https://mlsanity.com/paper/2010.03759/) (2020)
- [Generalized Out-of-Distribution Detection: A Survey](https://mlsanity.com/paper/2110.11334/) (2021)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [ReAct: Out-of-distribution Detection With Rectified Activations](https://mlsanity.com/paper/2111.12797/) (2021)
- [BCN20000: Dermoscopic Lesions in the Wild](https://mlsanity.com/paper/1908.02288/) (2019)
- [Multi-Scale Vision Longformer: A New Vision Transformer for High-Resolution Image Encoding](https://mlsanity.com/paper/2103.15358/) (2021)
- [Input complexity and out-of-distribution detection with likelihood-based generative models](https://mlsanity.com/paper/1909.11480/) (2019)
- [Semantically Coherent Out-of-Distribution Detection](https://mlsanity.com/paper/2108.11941/) (2021)
- [Does Your Dermatology Classifier Know What It Doesn't Know? Detecting the Long-Tail of Unseen Conditions](https://mlsanity.com/paper/2104.03829/) (2021)
- [Semi-supervised Medical Image Classification with Relation-driven Self-ensembling Model](https://mlsanity.com/paper/2005.07377/) (2020)
- [Detecting Out-of-Distribution Examples with In-distribution Examples and Gram Matrices](https://mlsanity.com/paper/1912.12510/) (2019)
- [Detecting Out-of-Distribution Inputs in Deep Neural Networks Using an Early-Layer Output](https://mlsanity.com/paper/1910.10307/) (2019)
- [Out-of-Distribution Detection in Dermatology using Input Perturbation and Subset Scanning](https://mlsanity.com/paper/2105.11160/) (2021)
- [Out-of-Distribution Detection for Skin Lesion Images with Deep Isolation Forest](https://mlsanity.com/paper/2003.09365/) (2020)
- [Out-of-Distribution Detection for Dermoscopic Image Classification](https://mlsanity.com/paper/2104.07819/) (2021)

## Abstract (arXiv)

The automatic detection of skin diseases via dermoscopic images can improve the efficiency in diagnosis and help doctors make more accurate judgments. However, conventional skin disease recognition systems may produce high confidence for out-of-distribution (OOD) data, which may become a major security vulnerability in practical applications. In this paper, we propose a multi-scale detection framework to detect out-of-distribution skin disease image data to ensure the robustness of the system. Our framework extracts features from different layers of the neural network. In the early layers, rectified activation is used to make the output features closer to the well-behaved distribution, and then an one-class SVM is trained to detect OOD data; in the penultimate layer, an adapted Gram matrix is used to calculate the features after rectified activation, and finally the layer with the best performance is chosen to compute a normality score. Experiments show that the proposed framework achieves superior performance when compared with other state-of-the-art methods in the task of skin disease recognition.