# From Risk Prediction to Risk Factors Interpretation. Comparison of Neural Networks and Classical Statistics for Dementia Prediction

arXiv: https://arxiv.org/abs/2301.06995 · HTML: https://mlsanity.com/paper/2301.06995/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 22 references that are in the map.
- First posted on arXiv 17 Jan 2023.

## Builds on (most cited first, 3 of 3)

- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [DeepSurv: Personalized Treatment Recommender System Using A Cox Proportional Hazards Deep Neural Network](https://mlsanity.com/paper/1606.00931/) (2016)
- [Deep learning: a statistical viewpoint](https://mlsanity.com/paper/2103.09177/) (2021)

## Abstract (arXiv)

It is proposed to investigate the onset of a disease D, based on several risk factors., with a specific interest in Alzheimer occurrence. For that purpose, two classes of techniques are available, whose properties are quite different in terms of interpretation, which is the focus of this paper: classical statistics based on probabilistic models and artificial intelligence (mainly neural networks) based on optimization algorithms. Both methods are good at prediction, with a preference for neural networks when the dimension of the potential predictors is high. But the advantage of the classical statistics is cognitive : the role of each factor is generally summarized in the value of a coefficient which is highly positive for a harmful factor, close to 0 for an irrelevant one, and highly negative for a beneficial one.