# Context-dependent Explainability and Contestability for Trustworthy Medical Artificial Intelligence: Misclassification Identification of Morbidity Recognition Models in Preterm Infants

arXiv: https://arxiv.org/abs/2212.08821 · HTML: https://mlsanity.com/paper/2212.08821/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 17 of its 94 references that are in the map.
- First posted on arXiv 17 Dec 2022.

## Builds on (most cited first, 17 of 17)

- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [Explainable Artificial Intelligence (XAI): Concepts, Taxonomies, Opportunities and Challenges toward Responsible AI](https://mlsanity.com/paper/1910.10045/) (2019)
- [A Survey Of Methods For Explaining Black Box Models](https://mlsanity.com/paper/1802.01933/) (2018)
- [CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning](https://mlsanity.com/paper/1711.05225/) (2017)
- [All Models are Wrong, but Many are Useful: Learning a Variable's Importance by Studying an Entire Class of Prediction Models Simultaneously](https://mlsanity.com/paper/1801.01489/) (2018)
- [What Clinicians Want: Contextualizing Explainable Machine Learning for Clinical End Use](https://mlsanity.com/paper/1905.05134/) (2019)
- [Human-Centered Explainable AI (XAI): From Algorithms to User Experiences](https://mlsanity.com/paper/2110.10790/) (2021)
- [The role of explainability in creating trustworthy artificial intelligence for health care: a comprehensive survey of the terminology, design choices, and evaluation strategies](https://mlsanity.com/paper/2007.15911/) (2020)
- [Unbox the Black-box for the Medical Explainable AI via Multi-modal and Multi-centre Data Fusion: A Mini-Review, Two Showcases and Beyond](https://mlsanity.com/paper/2102.01998/) (2021)
- [A Case for Humans-in-the-Loop: Decisions in the Presence of Erroneous Algorithmic Scores](https://mlsanity.com/paper/2002.08035/) (2020)
- [Measuring the Quality of Explanations: The System Causability Scale (SCS). Comparing Human and Machine Explanations](https://mlsanity.com/paper/1912.09024/) (2019)
- [CheXplain: Enabling Physicians to Explore and UnderstandData-Driven, AI-Enabled Medical Imaging Analysis](https://mlsanity.com/paper/2001.05149/) (2020)
- [Explainable AI for clinical and remote health applications: a survey on tabular and time series data](https://mlsanity.com/paper/2209.06528/) (2022)
- [Conceptualising Contestability: Perspectives on Contesting Algorithmic Decisions](https://mlsanity.com/paper/2103.01774/) (2021)
- [Learning Interpretable Anatomical Features Through Deep Generative Models: Application to Cardiac Remodeling](https://mlsanity.com/paper/1807.06843/) (2018)
- [Learning to Predict with Supporting Evidence: Applications to Clinical Risk Prediction](https://mlsanity.com/paper/2103.02768/) (2021)
- [CheXbreak: Misclassification Identification for Deep Learning Models Interpreting Chest X-rays](https://mlsanity.com/paper/2103.09957/) (2021)

## Built on by (most cited first, 1 of 1)

- [Explainable AI Systems Must Be Contestable: Here's How to Make It Happen](https://mlsanity.com/paper/2506.01662/) (2025)

## Abstract (arXiv)

Although machine learning (ML) models of AI achieve high performances in medicine, they are not free of errors. Empowering clinicians to identify incorrect model recommendations is crucial for engendering trust in medical AI. Explainable AI (XAI) aims to address this requirement by clarifying AI reasoning to support the end users. Several studies on biomedical imaging achieved promising results recently. Nevertheless, solutions for models using tabular data are not sufficient to meet the requirements of clinicians yet. This paper proposes a methodology to support clinicians in identifying failures of ML models trained with tabular data. We built our methodology on three main pillars: decomposing the feature set by leveraging clinical context latent space, assessing the clinical association of global explanations, and Latent Space Similarity (LSS) based local explanations. We demonstrated our methodology on ML-based recognition of preterm infant morbidities caused by infection. The risk of mortality, lifelong disability, and antibiotic resistance due to model failures was an open research question in this domain. We achieved to identify misclassification cases of two models with our approach. By contextualizing local explanations, our solution provides clinicians with actionable insights to support their autonomy for informed final decisions.