# Towards Practical Plug-and-Play Diffusion Models

arXiv: https://arxiv.org/abs/2212.05973 · HTML: https://mlsanity.com/paper/2212.05973/

## Key facts

- Cited by 20 papers in the map (data through 14 Oct 2026).
- Placed in Diffusion foundations and sampling, one of 14 directions in Diffusion models.
- Builds on 56 of its 64 references that are in the map.
- First posted on arXiv 12 Dec 2022.

## Placed in

- Diffusion models / [Diffusion foundations and sampling](https://mlsanity.com/diffusion/diffusion-foundations-and-sampling/)

## Builds on (most cited first, 30 of 56)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Training data-efficient image transformers & distillation through attention](https://mlsanity.com/paper/2012.12877/) (2020)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Auto-Encoding Variational Bayes](https://mlsanity.com/paper/1312.6114/) (2013)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [DreamBooth: Fine Tuning Text-to-Image Diffusion Models for Subject-Driven Generation](https://mlsanity.com/paper/2208.12242/) (2022)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [Large Scale GAN Training for High Fidelity Natural Image Synthesis](https://mlsanity.com/paper/1809.11096/) (2018)
- [Rethinking Atrous Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1706.05587/) (2017)
- [Density estimation using Real NVP](https://mlsanity.com/paper/1605.08803/) (2016)
- [Vision Transformers for Dense Prediction](https://mlsanity.com/paper/2103.13413/) (2021)
- [Imagen Video: High Definition Video Generation with Diffusion Models](https://mlsanity.com/paper/2210.02303/) (2022)
- [Towards Robust Monocular Depth Estimation: Mixing Datasets for Zero-shot Cross-dataset Transfer](https://mlsanity.com/paper/1907.01341/) (2019)
- [Variational Diffusion Models](https://mlsanity.com/paper/2107.00630/) (2021)
- [NICE: Non-linear Independent Components Estimation](https://mlsanity.com/paper/1410.8516/) (2014)

## Built on by (most cited first, 20 of 20)

- [Scaling Diffusion Transformers to 16 Billion Parameters](https://mlsanity.com/paper/2407.11633/) (2024)
- [StyleShot: A Snapshot on Any Style](https://mlsanity.com/paper/2407.01414/) (2024)
- [Efficient Diffusion Transformer Policies with Mixture of Expert Denoisers for Multitask Learning](https://mlsanity.com/paper/2412.12953/) (2024)
- [Multi-Architecture Multi-Expert Diffusion Models](https://mlsanity.com/paper/2306.04990/) (2023)
- [SplatFlow: Multi-View Rectified Flow Model for 3D Gaussian Splatting Synthesis](https://mlsanity.com/paper/2411.16443/) (2024)
- [Addressing Negative Transfer in Diffusion Models](https://mlsanity.com/paper/2306.00354/) (2023)
- [Understanding and Improving Training-free Loss-based Diffusion Guidance](https://mlsanity.com/paper/2403.12404/) (2024)
- [Switch Diffusion Transformer: Synergizing Denoising Tasks with Sparse Mixture-of-Experts](https://mlsanity.com/paper/2403.09176/) (2024)
- [Denoising Task Routing for Diffusion Models](https://mlsanity.com/paper/2310.07138/) (2023)
- [Denoising Task Difficulty-based Curriculum for Training Diffusion Models](https://mlsanity.com/paper/2403.10348/) (2024)
- [Text-to-3D by Stitching a Multi-view Reconstruction Network to a Video Generator](https://mlsanity.com/paper/2510.13454/) (2025)
- [Improving Efficiency of Diffusion Models via Multi-Stage Framework and Tailored Multi-Decoder Architectures](https://mlsanity.com/paper/2312.09181/) (2023)
- [TimeStep Master: Asymmetrical Mixture of Timestep LoRA Experts for Versatile and Efficient Diffusion Models in Vision](https://mlsanity.com/paper/2503.07416/) (2025)
- [Decouple-Then-Merge: Finetune Diffusion Models as Multi-Task Learning](https://mlsanity.com/paper/2410.06664/) (2024)
- [Simple Drop-in LoRA Conditioning on Attention Layers Will Improve Your Diffusion Model](https://mlsanity.com/paper/2405.03958/) (2024)
- [Early-Bird Diffusion: Investigating and Leveraging Timestep-Aware Early-Bird Tickets in Diffusion Models for Efficient Training](https://mlsanity.com/paper/2504.09606/) (2025)
- [Not All Parameters Matter: Masking Diffusion Models for Enhancing Generation Ability](https://mlsanity.com/paper/2505.03097/) (2025)
- [Stitched Value Model for Diffusion Alignment](https://mlsanity.com/paper/2605.19804/) (2026)
- [Clustering by Denoising: Latent plug-and-play diffusion for single-cell data](https://mlsanity.com/paper/2510.22835/) (2025)
- [Free-Lunch Augmentation by Revisiting Diffusion-Based Data Generation for Cross-Domain Few-Shot Object Detection](https://mlsanity.com/paper/2608.04394/) (2026)

## Abstract (arXiv)

Diffusion-based generative models have achieved remarkable success in image generation. Their guidance formulation allows an external model to plug-and-play control the generation process for various tasks without finetuning the diffusion model. However, the direct use of publicly available off-the-shelf models for guidance fails due to their poor performance on noisy inputs. For that, the existing practice is to fine-tune the guidance models with labeled data corrupted with noises. In this paper, we argue that this practice has limitations in two aspects: (1) performing on inputs with extremely various noises is too hard for a single guidance model; (2) collecting labeled datasets hinders scaling up for various tasks. To tackle the limitations, we propose a novel strategy that leverages multiple experts where each expert is specialized in a particular noise range and guides the reverse process of the diffusion at its corresponding timesteps. However, as it is infeasible to manage multiple networks and utilize labeled data, we present a practical guidance framework termed Practical Plug-And-Play (PPAP), which leverages parameter-efficient fine-tuning and data-free knowledge transfer. We exhaustively conduct ImageNet class conditional generation experiments to show that our method can successfully guide diffusion with small trainable parameters and no labeled data. Finally, we show that image classifiers, depth estimators, and semantic segmentation models can guide publicly available GLIDE through our framework in a plug-and-play manner. Our code is available at https://github.com/riiid/PPAP.