# Towards Practical Application of Deep Learning in Diagnosis of Alzheimer's Disease

arXiv: https://arxiv.org/abs/2212.04528 · HTML: https://mlsanity.com/paper/2212.04528/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 51 references that are in the map.
- First posted on arXiv 8 Dec 2022.

## Builds on (most cited first, 10 of 10)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [A Survey of Convolutional Neural Networks: Analysis, Applications, and Prospects](https://mlsanity.com/paper/2004.02806/) (2020)
- [Convolutional Neural Networks for Classification of Alzheimer's Disease: Overview and Reproducible Evaluation](https://mlsanity.com/paper/1904.07773/) (2019)
- [Alzheimer's Disease Diagnostics by Adaptation of 3D Convolutional Network](https://mlsanity.com/paper/1607.00455/) (2016)
- [Automatic Assessment of Alzheimer's Disease Diagnosis Based on Deep Learning Techniques](https://mlsanity.com/paper/2105.08446/) (2021)
- [Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: Evaluation in Alzheimer's disease](https://mlsanity.com/paper/2012.10294/) (2020)

## Abstract (arXiv)

Accurate diagnosis of Alzheimer's disease (AD) is both challenging and time consuming. With a systematic approach for early detection and diagnosis of AD, steps can be taken towards the treatment and prevention of the disease. This study explores the practical application of deep learning models for diagnosis of AD. Due to computational complexity, large training times and limited availability of labelled dataset, a 3D full brain CNN (convolutional neural network) is not commonly used, and researchers often prefer 2D CNN variants. In this study, full brain 3D version of well-known 2D CNNs were designed, trained and tested for diagnosis of various stages of AD. Deep learning approach shows good performance in differentiating various stages of AD for more than 1500 full brain volumes. Along with classification, the deep learning model is capable of extracting features which are key in differentiating the various categories. The extracted features align with meaningful anatomical landmarks, that are currently considered important in identification of AD by experts. An ensemble of all the algorithm was also tested and the performance of the ensemble algorithm was superior to any individual algorithm, further improving diagnosis ability. The 3D versions of the trained CNNs and their ensemble have the potential to be incorporated in software packages that can be used by physicians/radiologists to assist them in better diagnosis of AD.