# Reducing Domain Gap in Frequency and Spatial domain for Cross-modality Domain Adaptation on Medical Image Segmentation

arXiv: https://arxiv.org/abs/2211.15235 · HTML: https://mlsanity.com/paper/2211.15235/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- Builds on 20 of its 35 references that are in the map.
- First posted on arXiv 28 Nov 2022.

## Builds on (most cited first, 20 of 20)

- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [CyCADA: Cycle-Consistent Adversarial Domain Adaptation](https://mlsanity.com/paper/1711.03213/) (2017)
- [Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks](https://mlsanity.com/paper/1703.10593/) (2017)
- [Learning to Adapt Structured Output Space for Semantic Segmentation](https://mlsanity.com/paper/1802.10349/) (2018)
- [FDA: Fourier Domain Adaptation for Semantic Segmentation](https://mlsanity.com/paper/2004.05498/) (2020)
- [Domain Adaptation for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2102.09508/) (2021)
- [CHAOS Challenge -- Combined (CT-MR) Healthy Abdominal Organ Segmentation](https://mlsanity.com/paper/2001.06535/) (2020)
- [A Fourier-based Framework for Domain Generalization](https://mlsanity.com/paper/2105.11120/) (2021)
- [FSDR: Frequency Space Domain Randomization for Domain Generalization](https://mlsanity.com/paper/2103.02370/) (2021)
- [Unsupervised Bidirectional Cross-Modality Adaptation via Deeply Synergistic Image and Feature Alignment for Medical Image Segmentation](https://mlsanity.com/paper/2002.02255/) (2020)
- [Synergistic Image and Feature Adaptation: Towards Cross-Modality Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/1901.08211/) (2019)
- [Unsupervised Domain Adaptation in Semantic Segmentation: a Review](https://mlsanity.com/paper/2005.10876/) (2020)
- [SynSeg-Net: Synthetic Segmentation Without Target Modality Ground Truth](https://mlsanity.com/paper/1810.06498/) (2018)
- [Transfer Learning for Domain Adaptation in MRI: Application in Brain Lesion Segmentation](https://mlsanity.com/paper/1702.07841/) (2017)
- [Multi-Source Domain Adaptation with Collaborative Learning for Semantic Segmentation](https://mlsanity.com/paper/2103.04717/) (2021)
- [Coarse-to-Fine Domain Adaptive Semantic Segmentation with Photometric Alignment and Category-Center Regularization](https://mlsanity.com/paper/2103.13041/) (2021)
- [Semi-supervised Domain Adaptation based on Dual-level Domain Mixing for Semantic Segmentation](https://mlsanity.com/paper/2103.04705/) (2021)
- [PnP-AdaNet: Plug-and-Play Adversarial Domain Adaptation Network with a Benchmark at Cross-modality Cardiac Segmentation](https://mlsanity.com/paper/1812.07907/) (2018)
- [Randomized Histogram Matching: A Simple Augmentation for Unsupervised Domain Adaptation in Overhead Imagery](https://mlsanity.com/paper/2104.14032/) (2021)
- [Attention-based Cross-Layer Domain Alignment for Unsupervised Domain Adaptation](https://mlsanity.com/paper/2202.13310/) (2022)

## Built on by (most cited first, 10 of 10)

- [MAPSeg: Unified Unsupervised Domain Adaptation for Heterogeneous Medical Image Segmentation Based on 3D Masked Autoencoding and Pseudo-Labeling](https://mlsanity.com/paper/2303.09373/) (2023)
- [Diffuse-UDA: Addressing Unsupervised Domain Adaptation in Medical Image Segmentation with Appearance and Structure Aligned Diffusion Models](https://mlsanity.com/paper/2408.05985/) (2024)
- [Navigating Distribution Shifts in Medical Image Analysis: A Survey](https://mlsanity.com/paper/2411.05824/) (2024)
- [DDFP: Data-dependent Frequency Prompt for Source Free Domain Adaptation of Medical Image Segmentation](https://mlsanity.com/paper/2505.09927/) (2025)
- [Curvilinear Structure-preserving Unpaired Cross-domain Medical Image Translation](https://mlsanity.com/paper/2510.19679/) (2025)
- [Learning Label-Efficient Interpretable Medical Image Diagnosis via Semi-supervised Hypergraph Concept Bottleneck Model](https://mlsanity.com/paper/2606.01698/) (2026)
- [Multi-Disease-Aware Training Strategy for Cardiac MR Image Segmentation](https://mlsanity.com/paper/2503.17896/) (2025)
- [SSFMamba: Learning Symmetry-driven Spatial-Frequency Modeling for Physically Consistent 3D Medical Image Segmentation](https://mlsanity.com/paper/2508.03069/) (2025)
- [DUDE: Diffusion-Based Unsupervised Cross-Domain Image Retrieval](https://mlsanity.com/paper/2509.04193/) (2025)
- [Vision-Language Semantic Aggregation Leveraging Foundation Model for Generalizable Medical Image Segmentation](https://mlsanity.com/paper/2509.08570/) (2025)

## Abstract (arXiv)

Unsupervised domain adaptation (UDA) aims to learn a model trained on source domain and performs well on unlabeled target domain. In medical image segmentation field, most existing UDA methods depend on adversarial learning to address the domain gap between different image modalities, which is ineffective due to its complicated training process. In this paper, we propose a simple yet effective UDA method based on frequency and spatial domain transfer uner multi-teacher distillation framework. In the frequency domain, we first introduce non-subsampled contourlet transform for identifying domain-invariant and domain-variant frequency components (DIFs and DVFs), and then keep the DIFs unchanged while replacing the DVFs of the source domain images with that of the target domain images to narrow the domain gap. In the spatial domain, we propose a batch momentum update-based histogram matching strategy to reduce the domain-variant image style bias. Experiments on two cross-modality medical image segmentation datasets (cardiac, abdominal) show that our proposed method achieves superior performance compared to state-of-the-art methods.