# DoubleU-NetPlus: A Novel Attention and Context Guided Dual U-Net with Multi-Scale Residual Feature Fusion Network for Semantic Segmentation of Medical Images

arXiv: https://arxiv.org/abs/2211.14235 · HTML: https://mlsanity.com/paper/2211.14235/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 45 of its 92 references that are in the map.
- First posted on arXiv 25 Nov 2022.

## Builds on (most cited first, 30 of 45)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs](https://mlsanity.com/paper/1606.00915/) (2016)
- [CBAM: Convolutional Block Attention Module](https://mlsanity.com/paper/1807.06521/) (2018)
- [Identity Mappings in Deep Residual Networks](https://mlsanity.com/paper/1603.05027/) (2016)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation](https://mlsanity.com/paper/1511.00561/) (2015)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Generalised Dice overlap as a deep learning loss function for highly unbalanced segmentations](https://mlsanity.com/paper/1707.03237/) (2017)
- [Res2Net: A New Multi-scale Backbone Architecture](https://mlsanity.com/paper/1904.01169/) (2019)
- [RefineNet: Multi-Path Refinement Networks for High-Resolution Semantic Segmentation](https://mlsanity.com/paper/1611.06612/) (2016)
- [U2-Net: Going Deeper with Nested U-Structure for Salient Object Detection](https://mlsanity.com/paper/2005.09007/) (2020)
- [Attention Mechanisms in Computer Vision: A Survey](https://mlsanity.com/paper/2111.07624/) (2021)
- [CE-Net: Context Encoder Network for 2D Medical Image Segmentation](https://mlsanity.com/paper/1903.02740/) (2019)
- [Cascaded Partial Decoder for Fast and Accurate Salient Object Detection](https://mlsanity.com/paper/1904.08739/) (2019)
- [MultiResUNet : Rethinking the U-Net Architecture for Multimodal Biomedical Image Segmentation](https://mlsanity.com/paper/1902.04049/) (2019)
- [Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation](https://mlsanity.com/paper/1802.06955/) (2018)
- [Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformers](https://mlsanity.com/paper/2108.06932/) (2021)
- [DS-TransUNet:Dual Swin Transformer U-Net for Medical Image Segmentation](https://mlsanity.com/paper/2106.06716/) (2021)
- [DoubleU-Net: A Deep Convolutional Neural Network for Medical Image Segmentation](https://mlsanity.com/paper/2006.04868/) (2020)
- [Global Second-order Pooling Convolutional Networks](https://mlsanity.com/paper/1811.12006/) (2018)
- [W-Net: A Deep Model for Fully Unsupervised Image Segmentation](https://mlsanity.com/paper/1711.08506/) (2017)

## Abstract (arXiv)

Accurate segmentation of the region of interest in medical images can provide an essential pathway for devising effective treatment plans for life-threatening diseases. It is still challenging for U-Net, and its state-of-the-art variants, such as CE-Net and DoubleU-Net, to effectively model the higher-level output feature maps of the convolutional units of the network mostly due to the presence of various scales of the region of interest, intricacy of context environments, ambiguous boundaries, and multiformity of textures in medical images. In this paper, we exploit multi-contextual features and several attention strategies to increase networks' ability to model discriminative feature representation for more accurate medical image segmentation, and we present a novel dual U-Net-based architecture named DoubleU-NetPlus. The DoubleU-NetPlus incorporates several architectural modifications. In particular, we integrate EfficientNetB7 as the feature encoder module, a newly designed multi-kernel residual convolution module, and an adaptive feature re-calibrating attention-based atrous spatial pyramid pooling module to progressively and precisely accumulate discriminative multi-scale high-level contextual feature maps and emphasize the salient regions. In addition, we introduce a novel triple attention gate module and a hybrid triple attention module to encourage selective modeling of relevant medical image features. Moreover, to mitigate the gradient vanishing issue and incorporate high-resolution features with deeper spatial details, the standard convolution operation is replaced with the attention-guided residual convolution operations, ...