# Self-supervised iRegNet for the Registration of Longitudinal Brain MRI of Diffuse Glioma Patients

arXiv: https://arxiv.org/abs/2211.11025 · HTML: https://mlsanity.com/paper/2211.11025/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 9 of its 22 references that are in the map.
- First posted on arXiv 20 Nov 2022.

## Builds on (most cited first, 9 of 9)

- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [A Deep Learning Framework for Unsupervised Affine and Deformable Image Registration](https://mlsanity.com/paper/1809.06130/) (2018)
- [Deep Learning in Medical Image Registration: A Survey](https://mlsanity.com/paper/1903.02026/) (2019)
- [The Brain Tumor Sequence Registration (BraTS-Reg) Challenge: Establishing Correspondence Between Pre-Operative and Follow-up MRI Scans of Diffuse Glioma Patients](https://mlsanity.com/paper/2112.06979/) (2021)
- [DeepSeg: Deep Neural Network Framework for Automatic Brain Tumor Segmentation using Magnetic Resonance FLAIR Images](https://mlsanity.com/paper/2004.12333/) (2020)
- [Medical image registration using unsupervised deep neural network: A scoping literature review](https://mlsanity.com/paper/2208.01825/) (2022)

## Built on by (most cited first, 2 of 2)

- [Primitive Simultaneous Optimization of Similarity Metrics for Image Registration](https://mlsanity.com/paper/2304.01601/) (2023)
- [Data-driven registration and modeling of brain deformation for image-guided neurosurgery](https://mlsanity.com/paper/2602.10155/) (2026)

## Abstract (arXiv)

Reliable and accurate registration of patient-specific brain magnetic resonance imaging (MRI) scans containing pathologies is challenging due to tissue appearance changes. This paper describes our contribution to the Registration of the longitudinal brain MRI task of the Brain Tumor Sequence Registration Challenge 2022 (BraTS-Reg 2022). We developed an enhanced unsupervised learning-based method that extends the iRegNet. In particular, incorporating an unsupervised learning-based paradigm as well as several minor modifications to the network pipeline, allows the enhanced iRegNet method to achieve respectable results. Experimental findings show that the enhanced self-supervised model is able to improve the initial mean median registration absolute error (MAE) from 8.20 (7.62) mm to the lowest value of 3.51 (3.50) for the training set while achieving an MAE of 2.93 (1.63) mm for the validation set. Additional qualitative validation of this study was conducted through overlaying pre-post MRI pairs before and after the de-formable registration. The proposed method scored 5th place during the testing phase of the MICCAI BraTS-Reg 2022 challenge. The docker image to reproduce our BraTS-Reg submission results will be publicly available.