# Spatial Temporal Graph Convolution with Graph Structure Self-learning for Early MCI Detection

arXiv: https://arxiv.org/abs/2211.06161 · HTML: https://mlsanity.com/paper/2211.06161/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 6 of its 23 references that are in the map.
- First posted on arXiv 11 Nov 2022.

## Builds on (most cited first, 6 of 6)

- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [Learning Dynamic Graph Representation of Brain Connectome with Spatio-Temporal Attention](https://mlsanity.com/paper/2105.13495/) (2021)
- [FBNETGEN: Task-aware GNN-based fMRI Analysis via Functional Brain Network Generation](https://mlsanity.com/paper/2205.12465/) (2022)
- [Spatio-Temporal Graph Convolution for Resting-State fMRI Analysis](https://mlsanity.com/paper/2003.10613/) (2020)
- [Interpretable Graph Convolutional Network of Multi-Modality Brain Imaging for Alzheimer's Disease Diagnosis](https://mlsanity.com/paper/2204.13188/) (2022)

## Built on by (most cited first, 2 of 2)

- [MCDGLN: Masked Connection-based Dynamic Graph Learning Network for Autism Spectrum Disorder](https://mlsanity.com/paper/2409.06163/) (2024)
- [MHSA: A Multi-scale Hypergraph Network for Mild Cognitive Impairment Detection via Synchronous and Attentive Fusion](https://mlsanity.com/paper/2412.12149/) (2024)

## Abstract (arXiv)

Graph neural networks (GNNs) have been successfully applied to early mild cognitive impairment (EMCI) detection, with the usage of elaborately designed features constructed from blood oxygen level-dependent (BOLD) time series. However, few works explored the feasibility of using BOLD signals directly as features. Meanwhile, existing GNN-based methods primarily rely on hand-crafted explicit brain topology as the adjacency matrix, which is not optimal and ignores the implicit topological organization of the brain. In this paper, we propose a spatial temporal graph convolutional network with a novel graph structure self-learning mechanism for EMCI detection. The proposed spatial temporal graph convolution block directly exploits BOLD time series as input features, which provides an interesting view for rsfMRI-based preclinical AD diagnosis. Moreover, our model can adaptively learn the optimal topological structure and refine edge weights with the graph structure self-learning mechanism. Results on the Alzheimer's Disease Neuroimaging Initiative (ADNI) database show that our method outperforms state-of-the-art approaches. Biomarkers consistent with previous studies can be extracted from the model, proving the reliable interpretability of our method.