# High-Resolution Boundary Detection for Medical Image Segmentation with Piece-Wise Two-Sample T-Test Augmented Loss

arXiv: https://arxiv.org/abs/2211.02419 · HTML: https://mlsanity.com/paper/2211.02419/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 30 references that are in the map.
- First posted on arXiv 4 Nov 2022.

## Builds on (most cited first, 14 of 14)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [PraNet: Parallel Reverse Attention Network for Polyp Segmentation](https://mlsanity.com/paper/2006.11392/) (2020)
- [nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentation](https://mlsanity.com/paper/1809.10486/) (2018)
- [Boundary loss for highly unbalanced segmentation](https://mlsanity.com/paper/1812.07032/) (2018)
- [Inf-Net: Automatic COVID-19 Lung Infection Segmentation from CT Images](https://mlsanity.com/paper/2004.14133/) (2020)
- [Medical Image Segmentation Using Deep Learning: A Survey](https://mlsanity.com/paper/2009.13120/) (2020)
- [Boundary and Entropy-driven Adversarial Learning for Fundus Image Segmentation](https://mlsanity.com/paper/1906.11143/) (2019)
- [Boundary-aware Transformers for Skin Lesion Segmentation](https://mlsanity.com/paper/2110.03864/) (2021)
- [An Exploration of 2D and 3D Deep Learning Techniques for Cardiac MR Image Segmentation](https://mlsanity.com/paper/1709.04496/) (2017)
- [Psi-Net: Shape and boundary aware joint multi-task deep network for medical image segmentation](https://mlsanity.com/paper/1902.04099/) (2019)
- [Modified U-Net (mU-Net) with Incorporation of Object-Dependent High Level Features for Improved Liver and Liver-Tumor Segmentation in CT Images](https://mlsanity.com/paper/1911.00140/) (2019)
- [Offset Curves Loss for Imbalanced Problem in Medical Segmentation](https://mlsanity.com/paper/2012.02463/) (2020)
- [Multi-phase Liver Tumor Segmentation with Spatial Aggregation and Uncertain Region Inpainting](https://mlsanity.com/paper/2108.00911/) (2021)

## Abstract (arXiv)

Deep learning methods have contributed substantially to the rapid advancement of medical image segmentation, the quality of which relies on the suitable design of loss functions. Popular loss functions, including the cross-entropy and dice losses, often fall short of boundary detection, thereby limiting high-resolution downstream applications such as automated diagnoses and procedures. We developed a novel loss function that is tailored to reflect the boundary information to enhance the boundary detection. As the contrast between segmentation and background regions along the classification boundary naturally induces heterogeneity over the pixels, we propose the piece-wise two-sample t-test augmented (PTA) loss that is infused with the statistical test for such heterogeneity. We demonstrate the improved boundary detection power of the PTA loss compared to benchmark losses without a t-test component.