# Self Supervised Low Dose Computed Tomography Image Denoising Using Invertible Network Exploiting Inter Slice Congruence

arXiv: https://arxiv.org/abs/2211.01618 · HTML: https://mlsanity.com/paper/2211.01618/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 18 of its 31 references that are in the map.
- First posted on arXiv 3 Nov 2022.

## Builds on (most cited first, 18 of 18)

- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Perceptual Losses for Real-Time Style Transfer and Super-Resolution](https://mlsanity.com/paper/1603.08155/) (2016)
- [Density estimation using Real NVP](https://mlsanity.com/paper/1605.08803/) (2016)
- [Glow: Generative Flow with Invertible 1x1 Convolutions](https://mlsanity.com/paper/1807.03039/) (2018)
- [Deep Image Prior](https://mlsanity.com/paper/1711.10925/) (2017)
- [NICE: Non-linear Independent Components Estimation](https://mlsanity.com/paper/1410.8516/) (2014)
- [Noise2Noise: Learning Image Restoration without Clean Data](https://mlsanity.com/paper/1803.04189/) (2018)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Noise2Self: Blind Denoising by Self-Supervision](https://mlsanity.com/paper/1901.11365/) (2019)
- [Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network (RED-CNN)](https://mlsanity.com/paper/1702.00288/) (2017)
- [EnhanceNet: Single Image Super-Resolution Through Automated Texture Synthesis](https://mlsanity.com/paper/1612.07919/) (2016)
- [High-Quality Self-Supervised Deep Image Denoising](https://mlsanity.com/paper/1901.10277/) (2019)
- [Invertible Image Rescaling](https://mlsanity.com/paper/2005.05650/) (2020)
- [Hierarchical Conditional Flow: A Unified Framework for Image Super-Resolution and Image Rescaling](https://mlsanity.com/paper/2108.05301/) (2021)
- [Invertible Denoising Network: A Light Solution for Real Noise Removal](https://mlsanity.com/paper/2104.10546/) (2021)
- [Reversible GANs for Memory-efficient Image-to-Image Translation](https://mlsanity.com/paper/1902.02729/) (2019)
- [Cycle-free CycleGAN using Invertible Generator for Unsupervised Low-Dose CT Denoising](https://mlsanity.com/paper/2104.08538/) (2021)
- [Consensus Neural Network for Medical Imaging Denoising with Only Noisy Training Samples](https://mlsanity.com/paper/1906.03639/) (2019)

## Built on by (most cited first, 3 of 3)

- [Multi-Scale Texture Loss for CT denoising with GANs](https://mlsanity.com/paper/2403.16640/) (2024)
- [PPORLD-EDNetLDCT: A Proximal Policy Optimization-Based Reinforcement Learning Framework for Adaptive Low-Dose CT Denoising](https://mlsanity.com/paper/2509.03185/) (2025)
- [Projection Guided Personalized Federated Learning for Low Dose CT Denoising](https://mlsanity.com/paper/2603.13422/) (2026)

## Abstract (arXiv)

The resurgence of deep neural networks has created an alternative pathway for low-dose computed tomography denoising by learning a nonlinear transformation function between low-dose CT (LDCT) and normal-dose CT (NDCT) image pairs. However, those paired LDCT and NDCT images are rarely available in the clinical environment, making deep neural network deployment infeasible. This study proposes a novel method for self-supervised low-dose CT denoising to alleviate the requirement of paired LDCT and NDCT images. Specifically, we have trained an invertible neural network to minimize the pixel-based mean square distance between a noisy slice and the average of its two immediate adjacent noisy slices. We have shown the aforementioned is similar to training a neural network to minimize the distance between clean NDCT and noisy LDCT image pairs. Again, during the reverse mapping of the invertible network, the output image is mapped to the original input image, similar to cycle consistency loss. Finally, the trained invertible network's forward mapping is used for denoising LDCT images. Extensive experiments on two publicly available datasets showed that our method performs favourably against other existing unsupervised methods.