# Learning Melanocytic Cell Masks from Adjacent Stained Tissue

arXiv: https://arxiv.org/abs/2211.00646 · HTML: https://mlsanity.com/paper/2211.00646/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 4 of its 20 references that are in the map.
- First posted on arXiv 1 Nov 2022.

## Builds on (most cited first, 4 of 4)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Tversky loss function for image segmentation using 3D fully convolutional deep networks](https://mlsanity.com/paper/1706.05721/) (2017)
- [Whole-Slide Mitosis Detection in H&E Breast Histology Using PHH3 as a Reference to Train Distilled Stain-Invariant Convolutional Networks](https://mlsanity.com/paper/1808.05896/) (2018)
- [Epithelium segmentation using deep learning in H&E-stained prostate specimens with immunohistochemistry as reference standard](https://mlsanity.com/paper/1808.05883/) (2018)

## Built on by (most cited first, 1 of 1)

- [On the Value of PHH3 for Mitotic Figure Detection on H&E-stained Images](https://mlsanity.com/paper/2406.19899/) (2024)

## Abstract (arXiv)

Melanoma is one of the most aggressive forms of skin cancer, causing a large proportion of skin cancer deaths. However, melanoma diagnoses by pathologists shows low interrater reliability. As melanoma is a cancer of the melanocyte, there is a clear need to develop a melanocytic cell segmentation tool that is agnostic to pathologist variability and automates pixel-level annotation. Gigapixel-level pathologist labeling, however, is impractical. Herein, we propose a means to train deep neural networks for melanocytic cell segmentation from hematoxylin and eosin (H&E) stained sections and paired immunohistochemistry (IHC) of adjacent tissue sections, achieving a mean IOU of 0.64 despite imperfect ground-truth labels.