# Multi-view Contrastive Learning with Additive Margin for Adaptive Nasopharyngeal Carcinoma Radiotherapy Prediction

arXiv: https://arxiv.org/abs/2210.15201 · HTML: https://mlsanity.com/paper/2210.15201/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 22 references that are in the map.
- First posted on arXiv 27 Oct 2022.

## Builds on (most cited first, 10 of 10)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [Contrastive Multiview Coding](https://mlsanity.com/paper/1906.05849/) (2019)
- [Additive Margin Softmax for Face Verification](https://mlsanity.com/paper/1801.05599/) (2018)
- [Positional Contrastive Learning for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/2106.09157/) (2021)
- [ProCo: Prototype-aware Contrastive Learning for Long-tailed Medical Image Classification](https://mlsanity.com/paper/2209.00183/) (2022)
- [Multi-Label Image Classification with Contrastive Learning](https://mlsanity.com/paper/2107.11626/) (2021)
- [Distributed Contrastive Learning for Medical Image Segmentation](https://mlsanity.com/paper/2208.03808/) (2022)

## Abstract (arXiv)

The prediction of adaptive radiation therapy (ART) prior to radiation therapy (RT) for nasopharyngeal carcinoma (NPC) patients is important to reduce toxicity and prolong the survival of patients. Currently, due to the complex tumor micro-environment, a single type of high-resolution image can provide only limited information. Meanwhile, the traditional softmax-based loss is insufficient for quantifying the discriminative power of a model. To overcome these challenges, we propose a supervised multi-view contrastive learning method with an additive margin (MMCon). For each patient, four medical images are considered to form multi-view positive pairs, which can provide additional information and enhance the representation of medical images. In addition, the embedding space is learned by means of contrastive learning. NPC samples from the same patient or with similar labels will remain close in the embedding space, while NPC samples with different labels will be far apart. To improve the discriminative ability of the loss function, we incorporate a margin into the contrastive learning. Experimental result show this new learning objective can be used to find an embedding space that exhibits superior discrimination ability for NPC images.