# Retrieval-Augmented and Knowledge-Grounded Language Models for Faithful Clinical Medicine

arXiv: https://arxiv.org/abs/2210.12777 · HTML: https://mlsanity.com/paper/2210.12777/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 14 of its 35 references that are in the map.
- First posted on arXiv 23 Oct 2022.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 14 of 14)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Sentence-BERT: Sentence Embeddings using Siamese BERT-Networks](https://mlsanity.com/paper/1908.10084/) (2019)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [Learning Phrase Representations using RNN Encoder-Decoder for Statistical Machine Translation](https://mlsanity.com/paper/1406.1078/) (2014)
- [Microsoft COCO Captions: Data Collection and Evaluation Server](https://mlsanity.com/paper/1504.00325/) (2015)
- [Effective Approaches to Attention-based Neural Machine Translation](https://mlsanity.com/paper/1508.04025/) (2015)
- [Gated Graph Sequence Neural Networks](https://mlsanity.com/paper/1511.05493/) (2015)
- [ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmission](https://mlsanity.com/paper/1904.05342/) (2019)
- [Incorporating Copying Mechanism in Sequence-to-Sequence Learning](https://mlsanity.com/paper/1603.06393/) (2016)
- [Encoding Sentences with Graph Convolutional Networks for Semantic Role Labeling](https://mlsanity.com/paper/1703.04826/) (2017)

## Built on by (most cited first, 4 of 4)

- [When to Think, When to Speak: Learning Disclosure Policies for LLM Reasoning](https://mlsanity.com/paper/2605.03314/) (2026)
- [CLIN-LLM: A Safety-Constrained Hybrid Framework for Clinical Diagnosis and Treatment Generation](https://mlsanity.com/paper/2510.22609/) (2025)
- [The End of Reward Engineering: How LLMs Are Redefining Multi-Agent Coordination](https://mlsanity.com/paper/2601.08237/) (2026)
- [Leveraging Evidence-Guided LLMs to Enhance Trustworthy Depression Diagnosis](https://mlsanity.com/paper/2511.17947/) (2025)

## Abstract (arXiv)

Language models (LMs), including large language models (such as ChatGPT), have the potential to assist clinicians in generating various clinical notes. However, LMs are prone to produce ``hallucinations'', i.e., generated content that is not aligned with facts and knowledge. In this paper, we propose the Re3Writer method with retrieval-augmented generation and knowledge-grounded reasoning to enable LMs to generate faithful clinical texts. We demonstrate the effectiveness of our method in generating patient discharge instructions. It requires the LMs not to only understand the patients' long clinical documents, i.e., the health records during hospitalization, but also to generate critical instructional information provided both to carers and to the patient at the time of discharge. The proposed Re3Writer imitates the working patterns of physicians to first retrieve related working experience from historical instructions written by physicians, then reason related medical knowledge. Finally, it refines the retrieved working experience and reasoned medical knowledge to extract useful information, which is used to generate the discharge instructions for previously-unseen patients. Our experiments show that, using our method, the performance of five representative LMs can be substantially boosted across all metrics. Meanwhile, we show results from human evaluations to measure the effectiveness in terms of fluency, faithfulness, and comprehensiveness.