# HistoStarGAN: A Unified Approach to Stain Normalisation, Stain Transfer and Stain Invariant Segmentation in Renal Histopathology

arXiv: https://arxiv.org/abs/2210.09798 · HTML: https://mlsanity.com/paper/2210.09798/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 22 of its 48 references that are in the map.
- First posted on arXiv 18 Oct 2022.

## Builds on (most cited first, 22 of 22)

- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Progressive Growing of GANs for Improved Quality, Stability, and Variation](https://mlsanity.com/paper/1710.10196/) (2017)
- [Training Generative Adversarial Networks with Limited Data](https://mlsanity.com/paper/2006.06676/) (2020)
- [StarGAN v2: Diverse Image Synthesis for Multiple Domains](https://mlsanity.com/paper/1912.01865/) (2019)
- [StarGAN: Unified Generative Adversarial Networks for Multi-Domain Image-to-Image Translation](https://mlsanity.com/paper/1711.09020/) (2017)
- [Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks](https://mlsanity.com/paper/1703.10593/) (2017)
- [Quantifying the effects of data augmentation and stain color normalization in convolutional neural networks for computational pathology](https://mlsanity.com/paper/1902.06543/) (2019)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [StainGAN: Stain Style Transfer for Digital Histological Images](https://mlsanity.com/paper/1804.01601/) (2018)
- [Rethinking the Truly Unsupervised Image-to-Image Translation](https://mlsanity.com/paper/2006.06500/) (2020)
- [Selective Synthetic Augmentation with HistoGAN for Improved Histopathology Image Classification](https://mlsanity.com/paper/2111.06399/) (2021)
- [Structure-Preserving Multi-Domain Stain Color Augmentation using Style-Transfer with Disentangled Representations](https://mlsanity.com/paper/2107.12357/) (2021)
- [StainNet: a fast and robust stain normalization network](https://mlsanity.com/paper/2012.12535/) (2020)
- [Learning domain-agnostic visual representation for computational pathology using medically-irrelevant style transfer augmentation](https://mlsanity.com/paper/2102.01678/) (2021)
- [Pix2Pix-based Stain-to-Stain Translation: A Solution for Robust Stain Normalization in Histopathology Images Analysis](https://mlsanity.com/paper/2002.00647/) (2020)
- [Neural Stain-Style Transfer Learning using GAN for Histopathological Images](https://mlsanity.com/paper/1710.08543/) (2017)
- [Towards Histopathological Stain Invariance by Unsupervised Domain Augmentation using Generative Adversarial Networks](https://mlsanity.com/paper/2012.12413/) (2020)
- [Test-time image-to-image translation ensembling improves out-of-distribution generalization in histopathology](https://mlsanity.com/paper/2206.09769/) (2022)
- [Self-Attentive Adversarial Stain Normalization](https://mlsanity.com/paper/1909.01963/) (2019)
- [Strategies for Training Stain Invariant CNNs](https://mlsanity.com/paper/1810.10338/) (2018)
- [Self adversarial attack as an augmentation method for immunohistochemical stainings](https://mlsanity.com/paper/2103.11362/) (2021)

## Built on by (most cited first, 3 of 3)

- [HIEGNet: A Heterogenous Graph Neural Network Including the Immune Environment in Glomeruli Classification](https://mlsanity.com/paper/2506.02542/) (2025)
- [K-Stain: Keypoint-Driven Correspondence for H&E-to-IHC Virtual Staining](https://mlsanity.com/paper/2511.06709/) (2025)
- [DSA-CycleGAN: A Domain Shift Aware CycleGAN for Robust Multi-Stain Glomeruli Segmentation](https://mlsanity.com/paper/2604.18368/) (2026)

## Abstract (arXiv)

Virtual stain transfer is a promising area of research in Computational Pathology, which has a great potential to alleviate important limitations when applying deeplearningbased solutions such as lack of annotations and sensitivity to a domain shift. However, in the literature, the majority of virtual staining approaches are trained for a specific staining or stain combination, and their extension to unseen stainings requires the acquisition of additional data and training. In this paper, we propose HistoStarGAN, a unified framework that performs stain transfer between multiple stainings, stain normalisation and stain invariant segmentation, all in one inference of the model. We demonstrate the generalisation abilities of the proposed solution to perform diverse stain transfer and accurate stain invariant segmentation over numerous unseen stainings, which is the first such demonstration in the field. Moreover, the pre-trained HistoStar-GAN model can serve as a synthetic data generator, which paves the way for the use of fully annotated synthetic image data to improve the training of deep learning-based algorithms. To illustrate the capabilities of our approach, as well as the potential risks in the microscopy domain, inspired by applications in natural images, we generated KidneyArtPathology, a fully annotated artificial image dataset for renal pathology.