# The computational and learning benefits of Daleian neural networks

arXiv: https://arxiv.org/abs/2210.05961 · HTML: https://mlsanity.com/paper/2210.05961/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 12 Oct 2022.

## Built on by (most cited first, 2 of 2)

- [TIDE: Asymmetric Neural Circuits for Stabilized Temporal Inhibitory-Excitatory Dynamics](https://mlsanity.com/paper/2605.19403/) (2026)
- [Learning in Deep Networks under Dale's Constraint](https://mlsanity.com/paper/2608.06963/) (2026)

## Abstract (arXiv)

Dale's principle implies that biological neural networks are composed of neurons that are either excitatory or inhibitory. While the number of possible architectures of such Daleian networks is exponentially smaller than non-Daleian ones, the computational and functional implications of using Daleian networks by the brain are mostly unknown. Here, we use models of recurrent spiking neural networks and rate-based networks to show, surprisingly, that despite the structural limitations on Daleian networks, they can approximate the computation performed by non-Daleian networks to a very high degree of accuracy. Moreover, we find that Daleian networks are more functionally robust to synaptic noise. We then show that unlike non-Daleian networks, Daleian ones can learn efficiently by tuning single neuron features, nearly as well as learning by tuning individual synaptic weights - suggesting a simpler and more biologically plausible learning mechanism. We thus suggest that in addition to architectural simplicity, Dale's principle confers computational and learning benefits for biological networks, and offers new directions for constructing and training biologically-inspired artificial neural networks