# Unsupervised Domain Adaptive Fundus Image Segmentation with Few Labeled Source Data

arXiv: https://arxiv.org/abs/2210.04379 · HTML: https://mlsanity.com/paper/2210.04379/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 34 of its 45 references that are in the map.
- First posted on arXiv 10 Oct 2022.

## Builds on (most cited first, 30 of 34)

- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Domain-Adversarial Training of Neural Networks](https://mlsanity.com/paper/1505.07818/) (2015)
- [Unsupervised Domain Adaptation by Backpropagation](https://mlsanity.com/paper/1409.7495/) (2014)
- [Adversarial Discriminative Domain Adaptation](https://mlsanity.com/paper/1702.05464/) (2017)
- [CyCADA: Cycle-Consistent Adversarial Domain Adaptation](https://mlsanity.com/paper/1711.03213/) (2017)
- [AutoAugment: Learning Augmentation Policies from Data](https://mlsanity.com/paper/1805.09501/) (2018)
- [ADVENT: Adversarial Entropy Minimization for Domain Adaptation in Semantic Segmentation](https://mlsanity.com/paper/1811.12833/) (2018)
- [FDA: Fourier Domain Adaptation for Semantic Segmentation](https://mlsanity.com/paper/2004.05498/) (2020)
- [Fast AutoAugment](https://mlsanity.com/paper/1905.00397/) (2019)
- [REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus Photographs](https://mlsanity.com/paper/1910.03667/) (2019)
- [FSDR: Frequency Space Domain Randomization for Domain Generalization](https://mlsanity.com/paper/2103.02370/) (2021)
- [Learning Texture Invariant Representation for Domain Adaptation of Semantic Segmentation](https://mlsanity.com/paper/2003.00867/) (2020)
- [Prototypical Cross-domain Self-supervised Learning for Few-shot Unsupervised Domain Adaptation](https://mlsanity.com/paper/2103.16765/) (2021)
- [Cross-domain Object Detection through Coarse-to-Fine Feature Adaptation](https://mlsanity.com/paper/2003.10275/) (2020)
- [PixMatch: Unsupervised Domain Adaptation via Pixelwise Consistency Training](https://mlsanity.com/paper/2105.08128/) (2021)
- [Joint Optic Disc and Cup Segmentation Based on Multi-label Deep Network and Polar Transformation](https://mlsanity.com/paper/1801.00926/) (2018)
- [HarmoFL: Harmonizing Local and Global Drifts in Federated Learning on Heterogeneous Medical Images](https://mlsanity.com/paper/2112.10775/) (2021)
- [Source-Free Domain Adaptive Fundus Image Segmentation with Denoised Pseudo-Labeling](https://mlsanity.com/paper/2109.09735/) (2021)
- [Boundary and Entropy-driven Adversarial Learning for Fundus Image Segmentation](https://mlsanity.com/paper/1906.11143/) (2019)
- [Patch-based Output Space Adversarial Learning for Joint Optic Disc and Cup Segmentation](https://mlsanity.com/paper/1902.07519/) (2019)
- [Spectral Unsupervised Domain Adaptation for Visual Recognition](https://mlsanity.com/paper/2106.06112/) (2021)
- [Unsupervised Instance Segmentation in Microscopy Images via Panoptic Domain Adaptation and Task Re-weighting](https://mlsanity.com/paper/2005.02066/) (2020)
- [MT-UDA: Towards Unsupervised Cross-modality Medical Image Segmentation with Limited Source Labels](https://mlsanity.com/paper/2203.12454/) (2022)
- [Optic Disc and Cup Segmentation Methods for Glaucoma Detection with Modification of U-Net Convolutional Neural Network](https://mlsanity.com/paper/1704.00979/) (2017)
- [Domain Adaptive Nuclei Instance Segmentation and Classification via Category-aware Feature Alignment and Pseudo-labelling](https://mlsanity.com/paper/2207.01233/) (2022)
- [Few-Shot Domain Adaptation with Polymorphic Transformers](https://mlsanity.com/paper/2107.04805/) (2021)
- [HyperSegNAS: Bridging One-Shot Neural Architecture Search with 3D Medical Image Segmentation using HyperNet](https://mlsanity.com/paper/2112.10652/) (2021)
- [BiX-NAS: Searching Efficient Bi-directional Architecture for Medical Image Segmentation](https://mlsanity.com/paper/2106.14033/) (2021)
- [A Novel Domain Adaptation Framework for Medical Image Segmentation](https://mlsanity.com/paper/1810.05732/) (2018)
- [BI-GCN: Boundary-Aware Input-Dependent Graph Convolution Network for Biomedical Image Segmentation](https://mlsanity.com/paper/2110.14775/) (2021)

## Built on by (most cited first, 2 of 2)

- [SynthMix: Mixing up Aligned Synthesis for Medical Cross-Modality Domain Adaptation](https://mlsanity.com/paper/2305.04156/) (2023)
- [Unsupervised Domain Adaptation for Neuron Membrane Segmentation based on Structural Features](https://mlsanity.com/paper/2305.02569/) (2023)

## Abstract (arXiv)

Deep learning-based segmentation methods have been widely employed for automatic glaucoma diagnosis and prognosis. In practice, fundus images obtained by different fundus cameras vary significantly in terms of illumination and intensity. Although recent unsupervised domain adaptation (UDA) methods enhance the models' generalization ability on the unlabeled target fundus datasets, they always require sufficient labeled data from the source domain, bringing auxiliary data acquisition and annotation costs. To further facilitate the data efficiency of the cross-domain segmentation methods on the fundus images, we explore UDA optic disc and cup segmentation problems using few labeled source data in this work. We first design a Searching-based Multi-style Invariant Mechanism to diversify the source data style as well as increase the data amount. Next, a prototype consistency mechanism on the foreground objects is proposed to facilitate the feature alignment for each kind of tissue under different image styles. Moreover, a cross-style self-supervised learning stage is further designed to improve the segmentation performance on the target images. Our method has outperformed several state-of-the-art UDA segmentation methods under the UDA fundus segmentation with few labeled source data.