# Automated segmentation and morphological characterization of placental histology images based on a single labeled image

arXiv: https://arxiv.org/abs/2210.03566 · HTML: https://mlsanity.com/paper/2210.03566/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 50 references that are in the map.
- First posted on arXiv 7 Oct 2022.

## Builds on (most cited first, 13 of 13)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification](https://mlsanity.com/paper/1502.01852/) (2015)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [Wider or Deeper: Revisiting the ResNet Model for Visual Recognition](https://mlsanity.com/paper/1611.10080/) (2016)
- [Quantifying the effects of data augmentation and stain color normalization in convolutional neural networks for computational pathology](https://mlsanity.com/paper/1902.06543/) (2019)
- [Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networks](https://mlsanity.com/paper/1807.10225/) (2018)
- [Selective Synthetic Augmentation with HistoGAN for Improved Histopathology Image Classification](https://mlsanity.com/paper/2111.06399/) (2021)
- [GramGAN: Deep 3D Texture Synthesis From 2D Exemplars](https://mlsanity.com/paper/2006.16112/) (2020)
- [A Fully Convolutional Neural Network for Cardiac Segmentation in Short-Axis MRI](https://mlsanity.com/paper/1604.00494/) (2016)
- [Generative Image Translation for Data Augmentation in Colorectal Histopathology Images](https://mlsanity.com/paper/1910.05827/) (2019)
- [Gleason Grading of Histology Prostate Images through Semantic Segmentation via Residual U-Net](https://mlsanity.com/paper/2005.11368/) (2020)
- [Towards Deep Cellular Phenotyping in Placental Histology](https://mlsanity.com/paper/1804.03270/) (2018)
- [Resolution enhancement of placenta histological images using deep learning](https://mlsanity.com/paper/2208.00163/) (2022)

## Abstract (arXiv)

In this study, a novel method of data augmentation has been presented for the segmentation of placental histological images when the labeled data are scarce. This method generates new realizations of the placenta intervillous morphology while maintaining the general textures and orientations. As a result, a diversified artificial dataset of images is generated that can be used for training deep learning segmentation models. We have observed that on average the presented method of data augmentation led to a 42% decrease in the binary cross-entropy loss of the validation dataset compared to the common approach in the literature. Additionally, the morphology of the intervillous space is studied under the effect of the proposed image reconstruction technique, and the diversity of the artificially generated population is quantified. Due to the high resemblance of the generated images to the real ones, the applications of the proposed method may not be limited to placental histological images, and it is recommended that other types of tissues be investigated in future studies.