# A deep learning model for brain vessel segmentation in 3DRA with arteriovenous malformations

arXiv: https://arxiv.org/abs/2210.02416 · HTML: https://mlsanity.com/paper/2210.02416/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 6 of its 34 references that are in the map.
- First posted on arXiv 5 Oct 2022.

## Builds on (most cited first, 6 of 6)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Deeply-Supervised Nets](https://mlsanity.com/paper/1409.5185/) (2014)
- [clDice -- A Novel Topology-Preserving Loss Function for Tubular Structure Segmentation](https://mlsanity.com/paper/2003.07311/) (2020)
- [Combo Loss: Handling Input and Output Imbalance in Multi-Organ Segmentation](https://mlsanity.com/paper/1805.02798/) (2018)
- [Y-net: 3D intracranial artery segmentation using a convolutional autoencoder](https://mlsanity.com/paper/1712.07194/) (2017)

## Built on by (most cited first, 1 of 1)

- [Deep Learning for Vascular Segmentation and Applications in Phase Contrast Tomography Imaging](https://mlsanity.com/paper/2311.13319/) (2023)

## Abstract (arXiv)

Segmentation of brain arterio-venous malformations (bAVMs) in 3D rotational angiographies (3DRA) is still an open problem in the literature, with high relevance for clinical practice. While deep learning models have been applied for segmenting the brain vasculature in these images, they have never been used in cases with bAVMs. This is likely caused by the difficulty to obtain sufficiently annotated data to train these approaches. In this paper we introduce a first deep learning model for blood vessel segmentation in 3DRA images of patients with bAVMs. To this end, we densely annotated 5 3DRA volumes of bAVM cases and used these to train two alternative 3DUNet-based architectures with different segmentation objectives. Our results show that the networks reach a comprehensive coverage of relevant structures for bAVM analysis, much better than what is obtained using standard methods. This is promising for achieving a better topological and morphological characterisation of the bAVM structures of interest. Furthermore, the models have the ability to segment venous structures even when missing in the ground truth labelling, which is relevant for planning interventional treatments. Ultimately, these results could be used as more reliable first initial guesses, alleviating the cumbersome task of creating manual labels.