# VAESim: A probabilistic approach for self-supervised prototype discovery

arXiv: https://arxiv.org/abs/2209.12279 · HTML: https://mlsanity.com/paper/2209.12279/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 22 references that are in the map.
- First posted on arXiv 25 Sep 2022.

## Builds on (most cited first, 12 of 12)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Big Self-Supervised Models are Strong Semi-Supervised Learners](https://mlsanity.com/paper/2006.10029/) (2020)
- [MedMNIST v2 -- A large-scale lightweight benchmark for 2D and 3D biomedical image classification](https://mlsanity.com/paper/2110.14795/) (2021)
- [Big Self-Supervised Models Advance Medical Image Classification](https://mlsanity.com/paper/2101.05224/) (2021)
- [Deep Unsupervised Clustering with Gaussian Mixture Variational Autoencoders](https://mlsanity.com/paper/1611.02648/) (2016)
- [Variational Deep Embedding: An Unsupervised and Generative Approach to Clustering](https://mlsanity.com/paper/1611.05148/) (2016)
- [Deep k-Means: Jointly clustering with k-Means and learning representations](https://mlsanity.com/paper/1806.10069/) (2018)
- [Unsupervised Feature Learning with K-means and An Ensemble of Deep Convolutional Neural Networks for Medical Image Classification](https://mlsanity.com/paper/1906.03359/) (2019)

## Built on by (most cited first, 1 of 1)

- [Mitigating Batch Effects in Histopathology via Language-Mediated Robust Embedding Generation](https://mlsanity.com/paper/2606.28697/) (2026)

## Abstract (arXiv)

In medicine, curated image datasets often employ discrete labels to describe what is known to be a continuous spectrum of healthy to pathological conditions, such as e.g. the Alzheimer's Disease Continuum or other areas where the image plays a pivotal point in diagnosis. We propose an architecture for image stratification based on a conditional variational autoencoder. Our framework, VAESim, leverages a continuous latent space to represent the continuum of disorders and finds clusters during training, which can then be used for image/patient stratification. The core of the method learns a set of prototypical vectors, each associated with a cluster. First, we perform a soft assignment of each data sample to the clusters. Then, we reconstruct the sample based on a similarity measure between the sample embedding and the prototypical vectors of the clusters. To update the prototypical embeddings, we use an exponential moving average of the most similar representations between actual prototypes and samples in the batch size. We test our approach on the MNIST-handwritten digit dataset and on a medical benchmark dataset called PneumoniaMNIST. We demonstrate that our method outperforms baselines in terms of kNN accuracy measured on a classification task against a standard VAE (up to 15% improvement in performance) in both datasets, and also performs at par with classification models trained in a fully supervised way. We also demonstrate how our model outperforms current, end-to-end models for unsupervised stratification.