# Structure Guided Manifolds for Discovery of Disease Characteristics

arXiv: https://arxiv.org/abs/2209.11015 · HTML: https://mlsanity.com/paper/2209.11015/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 28 references that are in the map.
- First posted on arXiv 22 Sep 2022.

## Builds on (most cited first, 15 of 15)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Alias-Free Generative Adversarial Networks](https://mlsanity.com/paper/2106.12423/) (2021)
- [StarGAN v2: Diverse Image Synthesis for Multiple Domains](https://mlsanity.com/paper/1912.01865/) (2019)
- [StarGAN: Unified Generative Adversarial Networks for Multi-Domain Image-to-Image Translation](https://mlsanity.com/paper/1711.09020/) (2017)
- [StyleCLIP: Text-Driven Manipulation of StyleGAN Imagery](https://mlsanity.com/paper/2103.17249/) (2021)
- [Which Training Methods for GANs do actually Converge?](https://mlsanity.com/paper/1801.04406/) (2018)
- [Making Convolutional Networks Shift-Invariant Again](https://mlsanity.com/paper/1904.11486/) (2019)
- [StyleSpace Analysis: Disentangled Controls for StyleGAN Image Generation](https://mlsanity.com/paper/2011.12799/) (2020)
- [Convolutional Neural Networks for Classification of Alzheimer's Disease: Overview and Reproducible Evaluation](https://mlsanity.com/paper/1904.07773/) (2019)
- [Disentangled Representation Learning in Cardiac Image Analysis](https://mlsanity.com/paper/1903.09467/) (2019)
- [Residual and Plain Convolutional Neural Networks for 3D Brain MRI Classification](https://mlsanity.com/paper/1701.06643/) (2017)

## Abstract (arXiv)

In medical image analysis, the subtle visual characteristics of many diseases are challenging to discern, particularly due to the lack of paired data. For example, in mild Alzheimer's Disease (AD), brain tissue atrophy can be difficult to observe from pure imaging data, especially without paired AD and Cognitively Normal ( CN ) data for comparison. This work presents Disease Discovery GAN ( DiDiGAN), a weakly-supervised style-based framework for discovering and visualising subtle disease features. DiDiGAN learns a disease manifold of AD and CN visual characteristics, and the style codes sampled from this manifold are imposed onto an anatomical structural "blueprint" to synthesise paired AD and CN magnetic resonance images (MRIs). To suppress non-disease-related variations between the generated AD and CN pairs, DiDiGAN leverages a structural constraint with cycle consistency and anti-aliasing to enforce anatomical correspondence. When tested on the Alzheimer's Disease Neuroimaging Initiative ( ADNI) dataset, DiDiGAN showed key AD characteristics (reduced hippocampal volume, ventricular enlargement, and atrophy of cortical structures) through synthesising paired AD and CN scans. The qualitative results were backed up by automated brain volume analysis, where systematic pair-wise reductions in brain tissue structures were also measured