# 3D Cross-Pseudo Supervision (3D-CPS): A semi-supervised nnU-Net architecture for abdominal organ segmentation

arXiv: https://arxiv.org/abs/2209.08939 · HTML: https://mlsanity.com/paper/2209.08939/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 12 of its 21 references that are in the map.
- First posted on arXiv 19 Sep 2022.

## Builds on (most cited first, 12 of 12)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Semi-Supervised Semantic Segmentation with Cross Pseudo Supervision](https://mlsanity.com/paper/2106.01226/) (2021)
- [Deep Learning for Medical Image Analysis](https://mlsanity.com/paper/1708.08987/) (2017)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [A large annotated medical image dataset for the development and evaluation of segmentation algorithms](https://mlsanity.com/paper/1902.09063/) (2019)
- [nnU-Net: Self-adapting Framework for U-Net-Based Medical Image Segmentation](https://mlsanity.com/paper/1809.10486/) (2018)
- [AbdomenCT-1K: Is Abdominal Organ Segmentation A Solved Problem?](https://mlsanity.com/paper/2010.14808/) (2020)
- [Semi-supervised Medical Image Segmentation through Dual-task Consistency](https://mlsanity.com/paper/2009.04448/) (2020)
- [The state of the art in kidney and kidney tumor segmentation in contrast-enhanced CT imaging: Results of the KiTS19 Challenge](https://mlsanity.com/paper/1912.01054/) (2019)
- [Shape-aware Semi-supervised 3D Semantic Segmentation for Medical Images](https://mlsanity.com/paper/2007.10732/) (2020)
- [Transformation Consistent Self-ensembling Model for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/1903.00348/) (2019)

## Built on by (most cited first, 2 of 2)

- [SSS: Semi-Supervised SAM-2 with Efficient Prompting for Medical Imaging Segmentation](https://mlsanity.com/paper/2506.08949/) (2025)
- [Random Window Augmentations for Deep Learning Robustness in CT and Liver Tumor Segmentation](https://mlsanity.com/paper/2510.08116/) (2025)

## Abstract (arXiv)

Large curated datasets are necessary, but annotating medical images is a time-consuming, laborious, and expensive process. Therefore, recent supervised methods are focusing on utilizing a large amount of unlabeled data. However, to do so, is a challenging task. To address this problem, we propose a new 3D Cross-Pseudo Supervision (3D-CPS) method, a semi-supervised network architecture based on nnU-Net with the Cross-Pseudo Supervision method. We design a new nnU-Net based preprocessing. In addition, we set the semi-supervised loss weights to expand linearity with each epoch to prevent the model from low-quality pseudo-labels in the early training process. Our proposed method achieves an average dice similarity coefficient (DSC) of 0.881 and an average normalized surface distance (NSD) of 0.913 on the MICCAI FLARE2022 validation set (20 cases).