# Noise2SR: Learning to Denoise from Super-Resolved Single Noisy Fluorescence Image

arXiv: https://arxiv.org/abs/2209.06411 · HTML: https://mlsanity.com/paper/2209.06411/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 27 references that are in the map.
- First posted on arXiv 14 Sep 2022.

## Builds on (most cited first, 10 of 10)

- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [Noise2Noise: Learning Image Restoration without Clean Data](https://mlsanity.com/paper/1803.04189/) (2018)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Noise2Self: Blind Denoising by Self-Supervision](https://mlsanity.com/paper/1901.11365/) (2019)
- [A guide to convolution arithmetic for deep learning](https://mlsanity.com/paper/1603.07285/) (2016)
- [Neighbor2Neighbor: Self-Supervised Denoising from Single Noisy Images](https://mlsanity.com/paper/2101.02824/) (2021)
- [High-Quality Self-Supervised Deep Image Denoising](https://mlsanity.com/paper/1901.10277/) (2019)
- [A Poisson-Gaussian Denoising Dataset with Real Fluorescence Microscopy Images](https://mlsanity.com/paper/1812.10366/) (2018)

## Built on by (most cited first, 1 of 1)

- [Zero-Shot Image Denoising for High-Resolution Electron Microscopy](https://mlsanity.com/paper/2406.14264/) (2024)

## Abstract (arXiv)

Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to noise. Recently, a few self-supervised deep learning (DL) denoising methods have been proposed. However, the training efficiency and denoising performance of existing methods are relatively low in real scene noise removal. To address this issue, this paper proposed self-supervised image denoising method Noise2SR (N2SR) to train a simple and effective image denoising model based on single noisy observation. Our Noise2SR denoising model is designed for training with paired noisy images of different dimensions. Benefiting from this training strategy, Noise2SR is more efficiently self-supervised and able to restore more image details from a single noisy observation. Experimental results of simulated noise and real microscopy noise removal show that Noise2SR outperforms two blind-spot based self-supervised deep learning image denoising methods. We envision that Noise2SR has the potential to improve more other kind of scientific imaging quality.