# Lesion-Specific Prediction with Discriminator-Based Supervised Guided Attention Module Enabled GANs in Multiple Sclerosis

arXiv: https://arxiv.org/abs/2208.14533 · HTML: https://mlsanity.com/paper/2208.14533/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 26 references that are in the map.
- First posted on arXiv 30 Aug 2022.

## Builds on (most cited first, 11 of 11)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs](https://mlsanity.com/paper/1606.00915/) (2016)
- [Self-Attention Generative Adversarial Networks](https://mlsanity.com/paper/1805.08318/) (2018)
- [Learning to synthesise the ageing brain without longitudinal data](https://mlsanity.com/paper/1912.02620/) (2019)
- [On the Compactness, Efficiency, and Representation of 3D Convolutional Networks: Brain Parcellation as a Pretext Task](https://mlsanity.com/paper/1707.01992/) (2017)
- [TarGAN: Target-Aware Generative Adversarial Networks for Multi-modality Medical Image Translation](https://mlsanity.com/paper/2105.08993/) (2021)
- [A Longitudinal Method for Simultaneous Whole-Brain and Lesion Segmentation in Multiple Sclerosis](https://mlsanity.com/paper/2008.05117/) (2020)
- [Classification of Findings with Localized Lesions in Fundoscopic Images using a Regionally Guided CNN](https://mlsanity.com/paper/1811.00871/) (2018)

## Abstract (arXiv)

Multiple Sclerosis (MS) is a chronic neurological condition characterized by the development of lesions in the white matter of the brain. T2-fluid attenuated inversion recovery (FLAIR) brain magnetic resonance imaging (MRI) provides superior visualization and characterization of MS lesions, relative to other MRI modalities. Follow-up brain FLAIR MRI in MS provides helpful information for clinicians towards monitoring disease progression. In this study, we propose a novel modification to generative adversarial networks (GANs) to predict future lesion-specific FLAIR MRI for MS at fixed time intervals. We use supervised guided attention and dilated convolutions in the discriminator, which supports making an informed prediction of whether the generated images are real or not based on attention to the lesion area, which in turn has potential to help improve the generator to predict the lesion area of future examinations more accurately. We compared our method to several baselines and one state-of-art CF-SAGAN model [1]. In conclusion, our results indicate that the proposed method achieves higher accuracy and reduces the standard deviation of the prediction errors in the lesion area compared with other models with similar overall performance.