# Multimodal foundation models are better simulators of the human brain

arXiv: https://arxiv.org/abs/2208.08263 · HTML: https://mlsanity.com/paper/2208.08263/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- Builds on 34 of its 90 references that are in the map.
- First posted on arXiv 17 Aug 2022.

## Builds on (most cited first, 30 of 34)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Scaling Up Visual and Vision-Language Representation Learning With Noisy Text Supervision](https://mlsanity.com/paper/2102.05918/) (2021)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Visual Genome: Connecting Language and Vision Using Crowdsourced Dense Image Annotations](https://mlsanity.com/paper/1602.07332/) (2016)
- [RandAugment: Practical automated data augmentation with a reduced search space](https://mlsanity.com/paper/1909.13719/) (2019)
- [Align before Fuse: Vision and Language Representation Learning with Momentum Distillation](https://mlsanity.com/paper/2107.07651/) (2021)
- [Flickr30k Entities: Collecting Region-to-Phrase Correspondences for Richer Image-to-Sentence Models](https://mlsanity.com/paper/1505.04870/) (2015)
- [Bottom-Up and Top-Down Attention for Image Captioning and Visual Question Answering](https://mlsanity.com/paper/1707.07998/) (2017)
- [ViLT: Vision-and-Language Transformer Without Convolution or Region Supervision](https://mlsanity.com/paper/2102.03334/) (2021)
- [Conceptual 12M: Pushing Web-Scale Image-Text Pre-Training To Recognize Long-Tail Visual Concepts](https://mlsanity.com/paper/2102.08981/) (2021)
- [Frozen in Time: A Joint Video and Image Encoder for End-to-End Retrieval](https://mlsanity.com/paper/2104.00650/) (2021)
- [Unicoder-VL: A Universal Encoder for Vision and Language by Cross-modal Pre-training](https://mlsanity.com/paper/1908.06066/) (2019)
- [Multi-modal Transformer for Video Retrieval](https://mlsanity.com/paper/2007.10639/) (2020)
- [Large-Scale Adversarial Training for Vision-and-Language Representation Learning](https://mlsanity.com/paper/2006.06195/) (2020)
- [Generic Attention-model Explainability for Interpreting Bi-Modal and Encoder-Decoder Transformers](https://mlsanity.com/paper/2103.15679/) (2021)
- [ZeRO-Infinity: Breaking the GPU Memory Wall for Extreme Scale Deep Learning](https://mlsanity.com/paper/2104.07857/) (2021)
- [Just Ask: Learning to Answer Questions from Millions of Narrated Videos](https://mlsanity.com/paper/2012.00451/) (2020)
- [ERNIE-ViL: Knowledge Enhanced Vision-Language Representations Through Scene Graph](https://mlsanity.com/paper/2006.16934/) (2020)
- [Support-set bottlenecks for video-text representation learning](https://mlsanity.com/paper/2010.02824/) (2020)
- [Hierarchical Conditional Relation Networks for Video Question Answering](https://mlsanity.com/paper/2002.10698/) (2020)
- [Interpreting and improving natural-language processing (in machines) with natural language-processing (in the brain)](https://mlsanity.com/paper/1905.11833/) (2019)
- [Towards artificial general intelligence via a multimodal foundation model](https://mlsanity.com/paper/2110.14378/) (2021)
- [AVLnet: Learning Audio-Visual Language Representations from Instructional Videos](https://mlsanity.com/paper/2006.09199/) (2020)

## Built on by (most cited first, 10 of 10)

- [BrainCLIP: Bridging Brain and Visual-Linguistic Representation Via CLIP for Generic Natural Visual Stimulus Decoding](https://mlsanity.com/paper/2302.12971/) (2023)
- [Brain encoding models based on multimodal transformers can transfer across language and vision](https://mlsanity.com/paper/2305.12248/) (2023)
- [Deep Neural Networks and Brain Alignment: Brain Encoding and Decoding (Survey)](https://mlsanity.com/paper/2307.10246/) (2023)
- [Embedding-based Multimodal Learning on Pan-Squamous Cell Carcinomas for Improved Survival Outcomes](https://mlsanity.com/paper/2406.08521/) (2024)
- [There is more to graphs than meets the eye: Learning universal features with self-supervision](https://mlsanity.com/paper/2305.19871/) (2023)
- [Dynamic Traceback Learning for Medical Report Generation](https://mlsanity.com/paper/2401.13267/) (2024)
- [Large-scale Foundation Models and Generative AI for BigData Neuroscience](https://mlsanity.com/paper/2310.18377/) (2023)
- [Leveraging Vision-Language Large Models for Interpretable Video Action Recognition with Semantic Tokenization](https://mlsanity.com/paper/2509.05695/) (2025)
- [Uncovering Brain-Like Hierarchical Patterns in Vision-Language Models through fMRI-Based Neural Encoding](https://mlsanity.com/paper/2510.16870/) (2025)
- [Coarse-to-fine Hierarchical Architecture with Sequential Mamba for Brain Reconstruction](https://mlsanity.com/paper/2606.04772/) (2026)

## Abstract (arXiv)

Multimodal learning, especially large-scale multimodal pre-training, has developed rapidly over the past few years and led to the greatest advances in artificial intelligence (AI). Despite its effectiveness, understanding the underlying mechanism of multimodal pre-training models still remains a grand challenge. Revealing the explainability of such models is likely to enable breakthroughs of novel learning paradigms in the AI field. To this end, given the multimodal nature of the human brain, we propose to explore the explainability of multimodal learning models with the aid of non-invasive brain imaging technologies such as functional magnetic resonance imaging (fMRI). Concretely, we first present a newly-designed multimodal foundation model pre-trained on 15 million image-text pairs, which has shown strong multimodal understanding and generalization abilities in a variety of cognitive downstream tasks. Further, from the perspective of neural encoding (based on our foundation model), we find that both visual and lingual encoders trained multimodally are more brain-like compared with unimodal ones. Particularly, we identify a number of brain regions where multimodally-trained encoders demonstrate better neural encoding performance. This is consistent with the findings in existing studies on exploring brain multi-sensory integration. Therefore, we believe that multimodal foundation models are more suitable tools for neuroscientists to study the multimodal signal processing mechanisms in the human brain. Our findings also demonstrate the potential of multimodal foundation models as ideal computational simulators to promote both AI-for-brain and brain-for-AI research.