# Longitudinal Prediction of Postnatal Brain Magnetic Resonance Images via a Metamorphic Generative Adversarial Network

arXiv: https://arxiv.org/abs/2208.04825 · HTML: https://mlsanity.com/paper/2208.04825/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 22 of its 46 references that are in the map.
- First posted on arXiv 9 Aug 2022.

## Builds on (most cited first, 22 of 22)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Instance Normalization: The Missing Ingredient for Fast Stylization](https://mlsanity.com/paper/1607.08022/) (2016)
- [High-Resolution Image Synthesis and Semantic Manipulation with Conditional GANs](https://mlsanity.com/paper/1711.11585/) (2017)
- [A Review of Uncertainty Quantification in Deep Learning: Techniques, Applications and Challenges](https://mlsanity.com/paper/2011.06225/) (2020)
- [Multimodal Unsupervised Image-to-Image Translation](https://mlsanity.com/paper/1804.04732/) (2018)
- [Unpaired Image-to-Image Translation using Cycle-Consistent Adversarial Networks](https://mlsanity.com/paper/1703.10593/) (2017)
- [Unsupervised Image-to-Image Translation Networks](https://mlsanity.com/paper/1703.00848/) (2017)
- [Holistically-Nested Edge Detection](https://mlsanity.com/paper/1504.06375/) (2015)
- [DualGAN: Unsupervised Dual Learning for Image-to-Image Translation](https://mlsanity.com/paper/1704.02510/) (2017)
- [Aleatoric uncertainty estimation with test-time augmentation for medical image segmentation with convolutional neural networks](https://mlsanity.com/paper/1807.07356/) (2018)
- [Learning to Discover Cross-Domain Relations with Generative Adversarial Networks](https://mlsanity.com/paper/1703.05192/) (2017)
- [Bayesian SegNet: Model Uncertainty in Deep Convolutional Encoder-Decoder Architectures for Scene Understanding](https://mlsanity.com/paper/1511.02680/) (2015)
- [MedGAN: Medical Image Translation using GANs](https://mlsanity.com/paper/1806.06397/) (2018)
- [Translating and Segmenting Multimodal Medical Volumes with Cycle- and Shape-Consistency Generative Adversarial Network](https://mlsanity.com/paper/1802.09655/) (2018)
- [Medical Image Synthesis with Context-Aware Generative Adversarial Networks](https://mlsanity.com/paper/1612.05362/) (2016)
- [Diversified Texture Synthesis with Feed-forward Networks](https://mlsanity.com/paper/1703.01664/) (2017)
- [Cross-modality image synthesis from unpaired data using CycleGAN: Effects of gradient consistency loss and training data size](https://mlsanity.com/paper/1803.06629/) (2018)
- [Unpaired Brain MR-to-CT Synthesis using a Structure-Constrained CycleGAN](https://mlsanity.com/paper/1809.04536/) (2018)

## Built on by (most cited first, 1 of 1)

- [Risk Estimation of Knee Osteoarthritis Progression via Predictive Multi-task Modelling from Efficient Diffusion Model using X-ray Images](https://mlsanity.com/paper/2506.14560/) (2025)

## Abstract (arXiv)

Missing scans are inevitable in longitudinal studies due to either subject dropouts or failed scans. In this paper, we propose a deep learning framework to predict missing scans from acquired scans, catering to longitudinal infant studies. Prediction of infant brain MRI is challenging owing to the rapid contrast and structural changes particularly during the first year of life. We introduce a trustworthy metamorphic generative adversarial network (MGAN) for translating infant brain MRI from one time-point to another. MGAN has three key features: (i) Image translation leveraging spatial and frequency information for detail-preserving mapping; (ii) Quality-guided learning strategy that focuses attention on challenging regions. (iii) Multi-scale hybrid loss function that improves translation of tissue contrast and structural details. Experimental results indicate that MGAN outperforms existing GANs by accurately predicting both contrast and anatomical details.