# A Transformer-based Generative Adversarial Network for Brain Tumor Segmentation

arXiv: https://arxiv.org/abs/2207.14134 · HTML: https://mlsanity.com/paper/2207.14134/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 42 of its 72 references that are in the map.
- First posted on arXiv 28 Jul 2022.

## Builds on (most cited first, 30 of 42)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs](https://mlsanity.com/paper/1606.00915/) (2016)
- [SSD: Single Shot MultiBox Detector](https://mlsanity.com/paper/1512.02325/) (2015)
- [Fast R-CNN](https://mlsanity.com/paper/1504.08083/) (2015)
- [XLNet: Generalized Autoregressive Pretraining for Language Understanding](https://mlsanity.com/paper/1906.08237/) (2019)
- [YOLOv3: An Incremental Improvement](https://mlsanity.com/paper/1804.02767/) (2018)
- [Rich feature hierarchies for accurate object detection and semantic segmentation](https://mlsanity.com/paper/1311.2524/) (2013)
- [Conditional Generative Adversarial Nets](https://mlsanity.com/paper/1411.1784/) (2014)
- [YOLOv4: Optimal Speed and Accuracy of Object Detection](https://mlsanity.com/paper/2004.10934/) (2020)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [YOLO9000: Better, Faster, Stronger](https://mlsanity.com/paper/1612.08242/) (2016)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [InfoGAN: Interpretable Representation Learning by Information Maximizing Generative Adversarial Nets](https://mlsanity.com/paper/1606.03657/) (2016)
- [Conditional Image Synthesis With Auxiliary Classifier GANs](https://mlsanity.com/paper/1610.09585/) (2016)
- [Semantic Image Segmentation with Deep Convolutional Nets and Fully Connected CRFs](https://mlsanity.com/paper/1412.7062/) (2014)

## Built on by (most cited first, 4 of 4)

- [BrainVoxGen: Deep learning framework for synthesis of Ultrasound to MRI](https://mlsanity.com/paper/2310.08608/) (2023)
- [Deep Learning Framework with Multi-Head Dilated Encoders for Enhanced Segmentation of Cervical Cancer on Multiparametric Magnetic Resonance Imaging](https://mlsanity.com/paper/2306.11137/) (2023)
- [Brain Tumor Segmentation in MRI Images with 3D U-Net and Contextual Transformer](https://mlsanity.com/paper/2407.08470/) (2024)
- [Comparative Evaluation of Traditional Methods and Deep Learning for Brain Glioma Imaging. Review Paper](https://mlsanity.com/paper/2603.04796/) (2026)

## Abstract (arXiv)

Brain tumor segmentation remains a challenge in medical image segmentation tasks. With the application of transformer in various computer vision tasks, transformer blocks show the capability of learning long-distance dependency in global space, which is complementary with CNNs. In this paper, we proposed a novel transformer-based generative adversarial network to automatically segment brain tumors with multi-modalities MRI. Our architecture consists of a generator and a discriminator, which are trained in min-max game progress. The generator is based on a typical "U-shaped" encoder-decoder architecture, whose bottom layer is composed of transformer blocks with resnet. Besides, the generator is trained with deep supervision technology. The discriminator we designed is a CNN-based network with multi-scale L1 loss, which is proved to be effective for medical semantic image segmentation. To validate the effectiveness of our method, we conducted experiments on BRATS2015 dataset, achieving comparable or better performance than previous state-of-the-art methods.