# Deep neural network heatmaps capture Alzheimer's disease patterns reported in a large meta-analysis of neuroimaging studies

arXiv: https://arxiv.org/abs/2207.11352 · HTML: https://mlsanity.com/paper/2207.11352/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Builds on 23 of its 143 references that are in the map.
- First posted on arXiv 22 Jul 2022.

## Builds on (most cited first, 23 of 23)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift](https://mlsanity.com/paper/1502.03167/) (2015)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Going Deeper with Convolutions](https://mlsanity.com/paper/1409.4842/) (2014)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Deep Inside Convolutional Networks: Visualising Image Classification Models and Saliency Maps](https://mlsanity.com/paper/1312.6034/) (2013)
- [Explainable Artificial Intelligence (XAI): Concepts, Taxonomies, Opportunities and Challenges toward Responsible AI](https://mlsanity.com/paper/1910.10045/) (2019)
- [Learning Important Features Through Propagating Activation Differences](https://mlsanity.com/paper/1704.02685/) (2017)
- [Explanation in Artificial Intelligence: Insights from the Social Sciences](https://mlsanity.com/paper/1706.07269/) (2017)
- [Sanity Checks for Saliency Maps](https://mlsanity.com/paper/1810.03292/) (2018)
- [Striving for Simplicity: The All Convolutional Net](https://mlsanity.com/paper/1412.6806/) (2014)
- [Evaluating the visualization of what a Deep Neural Network has learned](https://mlsanity.com/paper/1509.06321/) (2015)
- [Methods for Interpreting and Understanding Deep Neural Networks](https://mlsanity.com/paper/1706.07979/) (2017)
- [Explaining NonLinear Classification Decisions with Deep Taylor Decomposition](https://mlsanity.com/paper/1512.02479/) (2015)
- [Real Time Image Saliency for Black Box Classifiers](https://mlsanity.com/paper/1705.07857/) (2017)
- [Layer-wise Relevance Propagation for Neural Networks with Local Renormalization Layers](https://mlsanity.com/paper/1604.00825/) (2016)
- [Visual Interpretability for Deep Learning: a Survey](https://mlsanity.com/paper/1802.00614/) (2018)
- [Diagnosis of Alzheimer's Disease via Multi-modality 3D Convolutional Neural Network](https://mlsanity.com/paper/1902.09904/) (2019)
- [DEEPMIR: A DEEP neural network for differential detection of cerebral Microbleeds and IRon deposits in MRI](https://mlsanity.com/paper/2010.00148/) (2020)
- [Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: Evaluation in Alzheimer's disease](https://mlsanity.com/paper/2012.10294/) (2020)

## Built on by (most cited first, 6 of 6)

- [Looking deeper into interpretable deep learning in neuroimaging: a comprehensive survey](https://mlsanity.com/paper/2307.09615/) (2023)
- [Explainable concept mappings of MRI: Revealing the mechanisms underlying deep learning-based brain disease classification](https://mlsanity.com/paper/2404.10433/) (2024)
- [Predicting recovery following stroke: deep learning, multimodal data and feature selection using explainable AI](https://mlsanity.com/paper/2310.19174/) (2023)
- [Transforming gradient-based techniques into interpretable methods](https://mlsanity.com/paper/2401.14434/) (2024)
- [The Role of Explainable AI in Revolutionizing Human Health Monitoring: A Review](https://mlsanity.com/paper/2409.07347/) (2024)
- [Unlocking Neural Transparency: Jacobian Maps for Explainable AI in Alzheimer's Detection](https://mlsanity.com/paper/2504.03230/) (2025)

## Abstract (arXiv)

Deep neural networks currently provide the most advanced and accurate machine learning models to distinguish between structural MRI scans of subjects with Alzheimer's disease and healthy controls. Unfortunately, the subtle brain alterations captured by these models are difficult to interpret because of the complexity of these multi-layer and non-linear models. Several heatmap methods have been proposed to address this issue and analyze the imaging patterns extracted from the deep neural networks, but no quantitative comparison between these methods has been carried out so far. In this work, we explore these questions by deriving heatmaps from Convolutional Neural Networks (CNN) trained using T1 MRI scans of the ADNI data set, and by comparing these heatmaps with brain maps corresponding to Support Vector Machines (SVM) coefficients. Three prominent heatmap methods are studied: Layer-wise Relevance Propagation (LRP), Integrated Gradients (IG), and Guided Grad-CAM (GGC). Contrary to prior studies where the quality of heatmaps was visually or qualitatively assessed, we obtained precise quantitative measures by computing overlap with a ground-truth map from a large meta-analysis that combined 77 voxel-based morphometry (VBM) studies independently from ADNI. Our results indicate that all three heatmap methods were able to capture brain regions covering the meta-analysis map and achieved better results than SVM coefficients. Among them, IG produced the heatmaps with the best overlap with the independent meta-analysis.