# Immunofluorescence Capillary Imaging Segmentation: Cases Study

arXiv: https://arxiv.org/abs/2207.06861 · HTML: https://mlsanity.com/paper/2207.06861/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 31 references that are in the map.
- First posted on arXiv 14 Jul 2022.

## Builds on (most cited first, 10 of 10)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Fully Convolutional Networks for Semantic Segmentation](https://mlsanity.com/paper/1411.4038/) (2014)
- [Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification](https://mlsanity.com/paper/1502.01852/) (2015)
- [DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs](https://mlsanity.com/paper/1606.00915/) (2016)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation](https://mlsanity.com/paper/1912.05074/) (2019)
- [Retina U-Net: Embarrassingly Simple Exploitation of Segmentation Supervision for Medical Object Detection](https://mlsanity.com/paper/1811.08661/) (2018)
- [An application of cascaded 3D fully convolutional networks for medical image segmentation](https://mlsanity.com/paper/1803.05431/) (2018)
- [Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models](https://mlsanity.com/paper/1801.00880/) (2018)
- [Intrapapillary Capillary Loop Classification in Magnification Endoscopy: Open Dataset and Baseline Methodology](https://mlsanity.com/paper/2102.09963/) (2021)

## Abstract (arXiv)

Nonunion is one of the challenges faced by orthopedics clinics for the technical difficulties and high costs in photographing interosseous capillaries. Segmenting vessels and filling capillaries are critical in understanding the obstacles encountered in capillary growth. However, existing datasets for blood vessel segmentation mainly focus on the large blood vessels of the body, and the lack of labeled capillary image datasets greatly limits the methodological development and applications of vessel segmentation and capillary filling. Here, we present a benchmark dataset, named IFCIS-155, consisting of 155 2D capillary images with segmentation boundaries and vessel fillings annotated by biomedical experts, and 19 large-scale, high-resolution 3D capillary images. To obtain better images of interosseous capillaries, we leverage state-of-the-art immunofluorescence imaging techniques to highlight the rich vascular morphology of interosseous capillaries. We conduct comprehensive experiments to verify the effectiveness of the dataset and the benchmarking deep learning models (eg UNet/UNet++ and the modified UNet/UNet++). Our work offers a benchmark dataset for training deep learning models for capillary image segmentation and provides a potential tool for future capillary research. The IFCIS-155 dataset and code are all publicly available at urlhttps://github.com/ncclabsustech/IFCIS-55.